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TargetCannabinoid receptor 1
LigandBDBM50218118
Substrate/Competitorn/a
Meas. Tech.ChEMBL_444838 (CHEMBL895093)
IC50 1100±n/a nM
Citation Dziadulewicz, EKBevan, SJBrain, CTCoote, PRCulshaw, AJDavis, AJEdwards, LJFisher, AJFox, AJGentry, CGroarke, AHart, TWHuber, WJames, IFKesingland, ALa Vecchia, LLoong, YLyothier, IMcNair, KO'Farrell, CPeacock, MPortmann, RSchopfer, UYaqoob, MZadrobilek, J Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration. J Med Chem50:3851-6 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cannabinoid receptor 1
Name:Cannabinoid receptor 1
Synonyms:CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:52868.96
Organism:Homo sapiens (Human)
Description:P21554
Residue:472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIA
VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF
HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM
WTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWK
AHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLL
AIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQ
PLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
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  Blast E-value cutoff:
BDBM50218118
n/a
NameBDBM50218118
Synonyms:CHEMBL244189 | [4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]naphthalene-1-ylmethanone
TypeSmall organic molecule
Emp. Form.C27H25NO3
Mol. Mass.411.4923
SMILESO=C(c1cccc2ccccc12)c1ccc(OCCN2CCOCC2)c2ccccc12
Structure
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