Reaction Details |
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Target | Growth hormone secretagogue receptor type 1 |
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Ligand | BDBM50222873 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_446527 (CHEMBL895698) |
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Ki | 1.8±n/a nM |
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Citation | Rudolph, J; Esler, WP; O'connor, S; Coish, PD; Wickens, PL; Brands, M; Bierer, DE; Bloomquist, BT; Bondar, G; Chen, L; Chuang, CY; Claus, TH; Fathi, Z; Fu, W; Khire, UR; Kristie, JA; Liu, XG; Lowe, DB; McClure, AC; Michels, M; Ortiz, AA; Ramsden, PD; Schoenleber, RW; Shelekhin, TE; Vakalopoulos, A; Tang, W; Wang, L; Yi, L; Gardell, SJ; Livingston, JN; Sweet, LJ; Bullock, WH Quinazolinone derivatives as orally available ghrelin receptor antagonists for the treatment of diabetes and obesity. J Med Chem50:5202-16 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Growth hormone secretagogue receptor type 1 |
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Name: | Growth hormone secretagogue receptor type 1 |
Synonyms: | Ghrelin receptor |
Type: | PROTEIN |
Mol. Mass.: | 41494.35 |
Organism: | Ovis aries |
Description: | ChEMBL_446527 |
Residue: | 366 |
Sequence: | MWNATRSEELGPNLTLPDLDWDAAPDNDSLTDELPPLFPAPLLAGVTATCVALFVVGIAG
NLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWHYRPWNLGDLLCKLFQ
FVSESCTYASVLTITALSVERYFAICFPLRAKVVITKGRVKLVVLAIWAVAFCSAWPIFM
LVGVEHENGTDPRDTNECRATEFAVRSGLLTIMVWVSSIFFFLPVFCLTVLYSLIGRKLW
RRRRSEVVVGASLRDQNHKQTVKMLAVVVFAFVLCWLPFHVGRYLFSKSFEPGSVEIAQI
SQYCNLVSFVLFYFSAAINPILYNIMSKKYRVAVFKLLGFEPFSQRKLSTLKDESSRAWT
ESSINT
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BDBM50222873 |
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n/a |
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Name | BDBM50222873 |
Synonyms: | 6-(4-chlorophenyl)-3-[(1-isopropylpiperidin-3-yl)methyl]-2-(2-methylphenyl)quinazolin-4(3H)-one | CHEMBL243700 |
Type | Small organic molecule |
Emp. Form. | C30H32ClN3O |
Mol. Mass. | 486.048 |
SMILES | CC(C)N1CCCC(Cn2c(nc3ccc(cc3c2=O)-c2ccc(Cl)cc2)-c2ccccc2C)C1 |w:7.7| |
Structure |
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