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Target5-hydroxytryptamine receptor 2C
LigandBDBM50222865
Substrate/Competitorn/a
Meas. Tech.ChEMBL_446533 (CHEMBL896830)
Ki>1000±n/a nM
Citation Rudolph, JEsler, WPO'connor, SCoish, PDWickens, PLBrands, MBierer, DEBloomquist, BTBondar, GChen, LChuang, CYClaus, THFathi, ZFu, WKhire, URKristie, JALiu, XGLowe, DBMcClure, ACMichels, MOrtiz, AARamsden, PDSchoenleber, RWShelekhin, TEVakalopoulos, ATang, WWang, LYi, LGardell, SJLivingston, JNSweet, LJBullock, WH Quinazolinone derivatives as orally available ghrelin receptor antagonists for the treatment of diabetes and obesity. J Med Chem50:5202-16 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
5-hydroxytryptamine receptor 2C
Name:5-hydroxytryptamine receptor 2C
Synonyms:5-HT-2C | 5-HT2C | 5-HT2C-INI | 5-HT2c VGI | 5-HTR2C | 5-hydroxytryptamine receptor 1C | 5-hydroxytryptamine receptor 2C (5-HT-2C) | 5-hydroxytryptamine receptor 2C (5HT-2C) | 5HT-1C | 5HT2C_HUMAN | HTR1C | HTR2C | Serotonin (5-HT3) receptor | Serotonin 2c (5-HT2c) receptor | Serotonin Receptor 2C
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:51836.79
Organism:Homo sapiens (Human)
Description:P28335
Residue:458
Sequence:
MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSI
VIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVW
PLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWA
ISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYV
LRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTM
QAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVC
SGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTN
EPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
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  Blast E-value cutoff:
BDBM50222865
n/a
NameBDBM50222865
Synonyms:6-(4-fluorophenyl)-2-isopropyl-3-[(1-isopropylpiperidin-3-yl)-methyl]quinazolin-4(3H)-one | CHEMBL244521
TypeSmall organic molecule
Emp. Form.C26H32FN3O
Mol. Mass.421.5502
SMILESCC(C)N1CCC[C@H](Cn2c(nc3ccc(cc3c2=O)-c2ccc(F)cc2)C(C)C)C1
Structure
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