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TargetGrowth hormone secretagogue receptor type 1
LigandBDBM50222867
Substrate/Competitorn/a
Meas. Tech.ChEMBL_446527 (CHEMBL895698)
Ki 0.86±n/a nM
Citation Rudolph, JEsler, WPO'connor, SCoish, PDWickens, PLBrands, MBierer, DEBloomquist, BTBondar, GChen, LChuang, CYClaus, THFathi, ZFu, WKhire, URKristie, JALiu, XGLowe, DBMcClure, ACMichels, MOrtiz, AARamsden, PDSchoenleber, RWShelekhin, TEVakalopoulos, ATang, WWang, LYi, LGardell, SJLivingston, JNSweet, LJBullock, WH Quinazolinone derivatives as orally available ghrelin receptor antagonists for the treatment of diabetes and obesity. J Med Chem50:5202-16 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Growth hormone secretagogue receptor type 1
Name:Growth hormone secretagogue receptor type 1
Synonyms:Ghrelin receptor
Type:PROTEIN
Mol. Mass.:41494.35
Organism:Ovis aries
Description:ChEMBL_446527
Residue:366
Sequence:
MWNATRSEELGPNLTLPDLDWDAAPDNDSLTDELPPLFPAPLLAGVTATCVALFVVGIAG
NLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWHYRPWNLGDLLCKLFQ
FVSESCTYASVLTITALSVERYFAICFPLRAKVVITKGRVKLVVLAIWAVAFCSAWPIFM
LVGVEHENGTDPRDTNECRATEFAVRSGLLTIMVWVSSIFFFLPVFCLTVLYSLIGRKLW
RRRRSEVVVGASLRDQNHKQTVKMLAVVVFAFVLCWLPFHVGRYLFSKSFEPGSVEIAQI
SQYCNLVSFVLFYFSAAINPILYNIMSKKYRVAVFKLLGFEPFSQRKLSTLKDESSRAWT
ESSINT
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  Blast E-value cutoff:
BDBM50222867
n/a
NameBDBM50222867
Synonyms:(S)-6-(4-fluorophenoxy)-3-((1-isopropylpiperidin-3-yl)methyl)-2-o-tolylquinazolin-4(3H)-one | 6-(4-fluorophenoxy)-3-{[(3S)-1-isopropylpiperidin-3-yl]methyl}-2-(2-methylphenyl)quinazolin-4(3H)-one | CHEMBL242564
TypeSmall organic molecule
Emp. Form.C30H32FN3O2
Mol. Mass.485.5924
SMILESCC(C)N1CCC[C@H](Cn2c(nc3ccc(Oc4ccc(F)cc4)cc3c2=O)-c2ccccc2C)C1
Structure
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