Reaction Details |
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Target | Coagulation factor X |
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Ligand | BDBM50216581 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_447824 (CHEMBL898074) |
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Ki | 360±n/a nM |
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Citation | Qiao, JX; Chang, CH; Cheney, DL; Morin, PE; Wang, GZ; King, SR; Wang, TC; Rendina, AR; Luettgen, JM; Knabb, RM; Wexler, RR; Lam, PY SAR and X-ray structures of enantiopure 1,2-cis-(1R,2S)-cyclopentyldiamine and cyclohexyldiamine derivatives as inhibitors of coagulation Factor Xa. Bioorg Med Chem Lett17:4419-27 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Coagulation factor X |
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Name: | Coagulation factor X |
Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
Type: | Enzyme |
Mol. Mass.: | 54726.60 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 488 |
Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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BDBM50216581 |
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n/a |
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Name | BDBM50216581 |
Synonyms: | 2,4-dichloro-N-{(1R,2S)-2-[4-(2-oxo-2H-pyridin-1-yl)-benzoylamino]-cyclopentyl}-benzamide | CHEMBL393986 |
Type | Small organic molecule |
Emp. Form. | C24H21Cl2N3O3 |
Mol. Mass. | 470.348 |
SMILES | Clc1ccc(C(=O)N[C@@H]2CCC[C@@H]2NC(=O)c2ccc(cc2)-n2ccccc2=O)c(Cl)c1 |
Structure |
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