Reaction Details |
| Report a problem with these data |
Target | Polyunsaturated fatty acid lipoxygenase ALOX12 |
---|
Ligand | BDBM50214969 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_449592 (CHEMBL898687) |
---|
IC50 | 580±n/a nM |
---|
Citation | Deschamps, JD; Gautschi, JT; Whitman, S; Johnson, TA; Gassner, NC; Crews, P; Holman, TR Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries. Bioorg Med Chem15:6900-8 (2007) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Polyunsaturated fatty acid lipoxygenase ALOX12 |
---|
Name: | Polyunsaturated fatty acid lipoxygenase ALOX12 |
Synonyms: | 12-LOX | 12-Lipoxygenase (12-LOX) | 12LO | ALOX12 | Arachidonate 12-lipoxygenase | Arachidonate 12-lipoxygenase, 12S-type | LOG12 | LOX12_HUMAN | Platelet 12-lipoxygenase | Platelet-type lipoxygenase 12 |
Type: | Protein |
Mol. Mass.: | 75689.18 |
Organism: | Homo sapiens (Human) |
Description: | P18054 |
Residue: | 663 |
Sequence: | MGRYRIRVATGAWLFSGSYNRVQLWLVGTRGEAELELQLRPARGEEEEFDHDVAEDLGLL
QFVRLRKHHWLVDDAWFCDRITVQGPGACAEVAFPCYRWVQGEDILSLPEGTARLPGDNA
LDMFQKHREKELKDRQQIYCWATWKEGLPLTIAADRKDDLPPNMRFHEEKRLDFEWTLKA
GALEMALKRVYTLLSSWNCLEDFDQIFWGQKSALAEKVRQCWQDDELFSYQFLNGANPML
LRRSTSLPSRLVLPSGMEELQAQLEKELQNGSLFEADFILLDGIPANVIRGEKQYLAAPL
VMLKMEPNGKLQPMVIQIQPPNPSSPTPTLFLPSDPPLAWLLAKSWVRNSDFQLHEIQYH
LLNTHLVAEVIAVATMRCLPGLHPIFKFLIPHIRYTMEINTRARTQLISDGGIFDKAVST
GGGGHVQLLRRAAAQLTYCSLCPPDDLADRGLLGLPGALYAHDALRLWEIIARYVEGIVH
LFYQRDDIVKGDPELQAWCREITEVGLCQAQDRGFPVSFQSQSQLCHFLTMCVFTCTAQH
AAINQGQLDWYAWVPNAPCTMRMPPPTTKEDVTMATVMGSLPDVRQACLQMAISWHLSRR
QPDMVPLGHHKEKYFSGPKPKAVLNQFRTDLEKLEKEITARNEQLDWPYEYLKPSCIENS
VTI
|
|
|
BDBM50214969 |
---|
n/a |
---|
Name | BDBM50214969 |
Synonyms: | 1,3,6-Trihydroxy-7-methoxy-2,8-bis-(3-methyl-but-2-enyl)-xanthen-9-one | 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-enyl)-9H-xanthen-9-one | 1,3,6-trihydroxy-7-methoxy-2,8-diprenylxanthone | CHEMBL323197 | Mangostin | alpha-mangostin |
Type | Small organic molecule |
Emp. Form. | C24H26O6 |
Mol. Mass. | 410.4596 |
SMILES | [#6]-[#8]-c1c(-[#8])cc2oc3cc(-[#8])c(-[#6]\[#6]=[#6](\[#6])-[#6])c(-[#8])c3c(=O)c2c1-[#6]\[#6]=[#6](\[#6])-[#6] |
Structure |
|