Reaction Details |
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Target | Serine/threonine-protein kinase Chk1 |
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Ligand | BDBM50222920 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_449978 (CHEMBL899086) |
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Ki | 0.200000±n/a nM |
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Citation | Teng, M; Zhu, J; Johnson, MD; Chen, P; Kornmann, J; Chen, E; Blasina, A; Register, J; Anderes, K; Rogers, C; Deng, Y; Ninkovic, S; Grant, S; Hu, Q; Lundgren, K; Peng, Z; Kania, RS Structure-based design and synthesis of (5-arylamino-2H-pyrazol-3-yl)-biphenyl-2',4'-diols as novel and potent human CHK1 inhibitors. J Med Chem50:5253-6 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase Chk1 |
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Name: | Serine/threonine-protein kinase Chk1 |
Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 54443.02 |
Organism: | Homo sapiens (Human) |
Description: | gi_166295192 |
Residue: | 476 |
Sequence: | MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
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BDBM50222920 |
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n/a |
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Name | BDBM50222920 |
Synonyms: | 4'-{5-[6-(sec-butylamino-methyl)-pyridin-3-ylamino]-1H-pyrazol-3-yl}-biphenyl-2,4-diol | CHEMBL392900 |
Type | Small organic molecule |
Emp. Form. | C25H27N5O2 |
Mol. Mass. | 429.5142 |
SMILES | CCC(C)NCc1ccc(Nc2cc(n[nH]2)-c2ccc(cc2)-c2ccc(O)cc2O)cn1 |
Structure |
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