| Reaction Details |
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 | Report a problem with these data |
| Target | Calcium/calmodulin-dependent protein kinase type 1 |
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| Ligand | BDBM50222913 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_450005 (CHEMBL899104) |
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| IC50 | 2130±n/a nM |
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| Citation |  Teng, M; Zhu, J; Johnson, MD; Chen, P; Kornmann, J; Chen, E; Blasina, A; Register, J; Anderes, K; Rogers, C; Deng, Y; Ninkovic, S; Grant, S; Hu, Q; Lundgren, K; Peng, Z; Kania, RS Structure-based design and synthesis of (5-arylamino-2H-pyrazol-3-yl)-biphenyl-2',4'-diols as novel and potent human CHK1 inhibitors. J Med Chem50:5253-6 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Calcium/calmodulin-dependent protein kinase type 1 |
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| Name: | Calcium/calmodulin-dependent protein kinase type 1 |
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| Synonyms: | CAMK1 | CaM kinase I | CaM kinase I alpha | CaM-KI | CaMKI-alpha | Calcium/calmodulin-dependent protein kinase type 1 | KCC1A_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 41325.04 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_655701 |
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| Residue: | 370 |
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| Sequence: | MLGAVEGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKE
GSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASR
LIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACG
TPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSP
YWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFAK
SKWKQAFNATAVVRHMRKLQLGTSQEGQGQTASHGELLTPVAGGPAAGCCCRDCCVEPGT
ELSPTLPHQL
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| BDBM50222913 |
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| n/a |
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| Name | BDBM50222913 |
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| Synonyms: | 4'-{5-[4-(isopropylamino-methyl)-phenylamino]-2H-pyrazol-3-yl}-biphenyl-2,4-diol | CHEMBL398606 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H26N4O2 |
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| Mol. Mass. | 414.4995 |
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| SMILES | CC(C)NCc1ccc(Nc2cc(n[nH]2)-c2ccc(cc2)-c2ccc(O)cc2O)cc1 |
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| Structure | 
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