| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-2 adrenergic receptor |
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| Ligand | BDBM50223443 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_450127 (CHEMBL900403) |
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| EC50 | 0.258000±n/a nM |
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| Citation |  Brown, AD; Bunnage, ME; Glossop, PA; Holbrook, M; Jones, RD; Lane, CA; Lewthwaite, RA; Mantell, S; Perros-Huguet, C; Price, DA; Webster, R The discovery of indole-derived long acting beta2-adrenoceptor agonists for the treatment of asthma and COPD. Bioorg Med Chem Lett17:6188-91 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-2 adrenergic receptor |
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| Name: | Beta-2 adrenergic receptor |
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| Synonyms: | ADRB2 | ADRB2R | ADRB2_HUMAN | B2AR | Beta-2 adrenoceptor | Beta-2 adrenoreceptor |
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| Type: | n/a |
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| Mol. Mass.: | 46461.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P07550 |
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| Residue: | 413 |
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| Sequence: | MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAK
FERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTAS
IETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQE
AINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRF
HVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQD
NLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNT
GEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
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| BDBM50223443 |
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| n/a |
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| Name | BDBM50223443 |
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| Synonyms: | CHEMBL391308 | N-(2,6-dimethoxybenzyl)-5-((R)-2-((R)-2-hydroxy-2-(4-hydroxy-3-(hydroxymethyl)phenyl)ethylamino)butyl)-1H-indole-2-carboxamide |
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| Type | Small organic molecule |
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| Emp. Form. | C31H37N3O6 |
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| Mol. Mass. | 547.642 |
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| SMILES | CC[C@H](Cc1ccc2[nH]c(cc2c1)C(=O)NCc1c(OC)cccc1OC)NC[C@H](O)c1ccc(O)c(CO)c1 |
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| Structure | 
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