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TargetSigma non-opioid intracellular receptor 1
LigandBDBM50225872
Substrate/Competitorn/a
Meas. Tech.ChEMBL_451646 (CHEMBL901857)
Ki 126±n/a nM
Citation Geiger, CZelenka, CWeigl, MFröhlich, RWibbeling, BLehmkuhl, KSchepmann, DGrünert, RBednarski, PJWünsch, B Synthesis of bicyclic sigma receptor ligands with cytotoxic activity. J Med Chem50:6144-53 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sigma non-opioid intracellular receptor 1
Name:Sigma non-opioid intracellular receptor 1
Synonyms:OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:Protein
Mol. Mass.:25307.17
Organism:Cavia porcellus (Guinea pig)
Description:Q60492
Residue:223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSK
LIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
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  Blast E-value cutoff:
BDBM50225872
n/a
NameBDBM50225872
Synonyms:(+)-(1S,2R,5R)-6-benzyl-2-methoxy-8-(4-methoxybenzyl)-6,8-diazabicyclo[3.2.2]nonane | CHEMBL236866
TypeSmall organic molecule
Emp. Form.C23H30N2O2
Mol. Mass.366.4965
SMILESCO[C@@H]1CC[C@@H]2CN(Cc3ccc(OC)cc3)[C@H]1CN2Cc1ccccc1 |TLB:8:7:19.18:4.3.2,1:2:19.18:6.7|
Structure
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