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TargetC-X-C chemokine receptor type 2
LigandBDBM50203025
Substrate/Competitorn/a
Meas. Tech.ChEMBL_454110 (CHEMBL903301)
IC50 20±n/a nM
Citation McCleland, BW; Davis, RS; Palovich, MR; Widdowson, KL; Werner, ML; Burman, M; Foley, JJ; Schmidt, DB; Sarau, HM; Rogers, M; Salyers, KL; Gorycki, PD; Roethke, TJ; Stelman, GJ; Azzarano, LM; Ward, KW; Busch-Petersen, J Comparison of N,N'-diarylsquaramides and N,N'-diarylureas as antagonists of the CXCR2 chemokine receptor. Bioorg Med Chem Lett17:1713-7 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
C-X-C chemokine receptor type 2
Name:C-X-C chemokine receptor type 2
Synonyms:C-X-C chemokine receptor type 2 (CXCR-2) | C-X-C chemokine receptor type 2 (CXCR2) | CD_antigen=CD182 | CDw128b | CXCR-2 | CXCR2 | CXCR2_HUMAN | Chemokine receptor type 2 (CXCR2) | GRO/MGSA receptor | High affinity interleukin-8 receptor B | IL-8 receptor type 2 | IL-8R B | IL8RB | Interleukin-8 receptor B
Type:Protein
Mol. Mass.:40767.88
Organism:Homo sapiens (Human)
Description:P25025
Residue:360
Sequence:
MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFL
LSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCK
VVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPV
LLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFK
AHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATE
ILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
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  Blast E-value cutoff:
BDBM50203025
n/a
NameBDBM50203025
Synonyms:3-(4-chloro-2-hydroxy-3-(4-methyl-1,4-diazepan-1-ylsulfonyl)phenylamino)-4-(2-chlorophenylamino)cyclobut-3-ene-1,2-dione hydrochloride | CHEMBL537441
TypeSmall organic molecule
Emp. Form.C22H22Cl2N4O5S
Mol. Mass.525.405
SMILESCN1CCCN(CC1)S(=O)(=O)c1c(Cl)ccc(Nc2c(Nc3ccccc3Cl)c(=O)c2=O)c1O
Structure
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