| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidine kinase |
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| Ligand | BDBM50206484 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_454748 (CHEMBL886771) |
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| IC50 | 845000±n/a nM |
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| Citation |  Ciliberti, N; Manfredini, S; Angusti, A; Durini, E; Solaroli, N; Vertuani, S; Buzzoni, L; Bonache, MC; Ben-Shalom, E; Karlsson, A; Saada, A; Balzarini, J Novel selective human mitochondrial kinase inhibitors: design, synthesis and enzymatic activity. Bioorg Med Chem15:3065-81 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thymidine kinase |
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| Name: | Thymidine kinase |
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| Synonyms: | KITH_VZVD | TK |
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| Type: | PROTEIN |
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| Mol. Mass.: | 37819.99 |
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| Organism: | Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) |
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| Description: | ChEMBL_444706 |
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| Residue: | 341 |
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| Sequence: | MSTDKTDVKMGVLRIYLDGAYGIGKTTAAEEFLHHFAITPNRILLIGEPLSYWRNLAGED
AICGIYGTQTRRLNGDVSPEDAQRLTAHFQSLFCSPHAIMHAKISALMDTSTSDLVQVNK
EPYKIMLSDRHPIASTICFPLSRYLVGDMSPAALPGLLFTLPAEPPGTNLVVCTVSLPSH
LSRVSKRARPGETVNLPFVMVLRNVYIMLINTIIFLKTNNWHAGWNTLSFCNDVFKQKLQ
KSECIKLREVPGIEDTLFAVLKLPELCGEFGNILPLWAWGMETLSNCSRSMSPFVLSLEQ
TPQHAAQELKTLLPQMTPANMSSGAWNILKELVNAVQDNTS
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| BDBM50206484 |
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| n/a |
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| Name | BDBM50206484 |
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| Synonyms: | (2R,3S,4R,5R)-2-(5-((E)-2-bromovinyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-3-yl decanoate | CHEMBL400618 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H31BrN2O7 |
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| Mol. Mass. | 503.384 |
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| SMILES | CCCCCCCCCC(=O)O[C@H]1[C@H](O)[C@@H](CO)O[C@H]1n1cc(C=CBr)c(=O)[nH]c1=O |w:24.25| |
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| Structure | 
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