Reaction Details |
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Target | Thymidine kinase |
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Ligand | BDBM50206491 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_454748 (CHEMBL886771) |
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IC50 | 3200±n/a nM |
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Citation | Ciliberti, N; Manfredini, S; Angusti, A; Durini, E; Solaroli, N; Vertuani, S; Buzzoni, L; Bonache, MC; Ben-Shalom, E; Karlsson, A; Saada, A; Balzarini, J Novel selective human mitochondrial kinase inhibitors: design, synthesis and enzymatic activity. Bioorg Med Chem15:3065-81 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Thymidine kinase |
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Name: | Thymidine kinase |
Synonyms: | KITH_VZVD | TK |
Type: | PROTEIN |
Mol. Mass.: | 37819.99 |
Organism: | Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) |
Description: | ChEMBL_444706 |
Residue: | 341 |
Sequence: | MSTDKTDVKMGVLRIYLDGAYGIGKTTAAEEFLHHFAITPNRILLIGEPLSYWRNLAGED
AICGIYGTQTRRLNGDVSPEDAQRLTAHFQSLFCSPHAIMHAKISALMDTSTSDLVQVNK
EPYKIMLSDRHPIASTICFPLSRYLVGDMSPAALPGLLFTLPAEPPGTNLVVCTVSLPSH
LSRVSKRARPGETVNLPFVMVLRNVYIMLINTIIFLKTNNWHAGWNTLSFCNDVFKQKLQ
KSECIKLREVPGIEDTLFAVLKLPELCGEFGNILPLWAWGMETLSNCSRSMSPFVLSLEQ
TPQHAAQELKTLLPQMTPANMSSGAWNILKELVNAVQDNTS
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BDBM50206491 |
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n/a |
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Name | BDBM50206491 |
Synonyms: | 1-beta-D-arabinofuranosyl-5-(2-bromovinyl)uracil | 5-((E)-2-Bromo-vinyl)-1-((2R,3S,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-4-hydroxy-1H-pyrimidin-2-one | CHEMBL70046 | SORIVUDINE |
Type | Small organic molecule |
Emp. Form. | C11H13BrN2O6 |
Mol. Mass. | 349.135 |
SMILES | OC[C@H]1O[C@H]([C@@H](O)[C@@H]1O)n1cc(C=CBr)c(=O)[nH]c1=O |w:13.14| |
Structure |
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