| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Thymidine kinase |
|---|
| Ligand | BDBM50206495 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_454748 (CHEMBL886771) |
|---|
| IC50 | 39000±n/a nM |
|---|
| Citation |  Ciliberti, N; Manfredini, S; Angusti, A; Durini, E; Solaroli, N; Vertuani, S; Buzzoni, L; Bonache, MC; Ben-Shalom, E; Karlsson, A; Saada, A; Balzarini, J Novel selective human mitochondrial kinase inhibitors: design, synthesis and enzymatic activity. Bioorg Med Chem15:3065-81 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Thymidine kinase |
|---|
| Name: | Thymidine kinase |
|---|
| Synonyms: | KITH_VZVD | TK |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 37819.99 |
|---|
| Organism: | Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) |
|---|
| Description: | ChEMBL_444706 |
|---|
| Residue: | 341 |
|---|
| Sequence: | MSTDKTDVKMGVLRIYLDGAYGIGKTTAAEEFLHHFAITPNRILLIGEPLSYWRNLAGED
AICGIYGTQTRRLNGDVSPEDAQRLTAHFQSLFCSPHAIMHAKISALMDTSTSDLVQVNK
EPYKIMLSDRHPIASTICFPLSRYLVGDMSPAALPGLLFTLPAEPPGTNLVVCTVSLPSH
LSRVSKRARPGETVNLPFVMVLRNVYIMLINTIIFLKTNNWHAGWNTLSFCNDVFKQKLQ
KSECIKLREVPGIEDTLFAVLKLPELCGEFGNILPLWAWGMETLSNCSRSMSPFVLSLEQ
TPQHAAQELKTLLPQMTPANMSSGAWNILKELVNAVQDNTS
|
|
|
|---|
| BDBM50206495 |
|---|
| n/a |
|---|
| Name | BDBM50206495 |
|---|
| Synonyms: | 1-[2'-O-(4-methoxyphenylacetyl)-beta-D-arabinofuranosyl]-5(E)-(2-bromovinyl)uracil | CHEMBL241408 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H21BrN2O8 |
|---|
| Mol. Mass. | 497.293 |
|---|
| SMILES | COc1ccc(CC(=O)O[C@H]2[C@H](O)[C@@H](CO)O[C@H]2n2cc(C=CBr)c(=O)[nH]c2=O)cc1 |w:22.23| |
|---|
| Structure | 
|
|---|
Search and Browse
