Reaction Details |
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Target | Glycogen synthase kinase-3 beta |
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Ligand | BDBM50207807 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_454902 (CHEMBL886931) |
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IC50 | 30±n/a nM |
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Citation | Zhang, HC; Boñaga, LV; Ye, H; Derian, CK; Damiano, BP; Maryanoff, BE Novel bis(indolyl)maleimide pyridinophanes that are potent, selective inhibitors of glycogen synthase kinase-3. Bioorg Med Chem Lett17:2863-8 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Glycogen synthase kinase-3 beta |
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Name: | Glycogen synthase kinase-3 beta |
Synonyms: | GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B |
Type: | Enzyme |
Mol. Mass.: | 46756.38 |
Organism: | Homo sapiens (Human) |
Description: | P49841 |
Residue: | 420 |
Sequence: | MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
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BDBM50207807 |
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n/a |
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Name | BDBM50207807 |
Synonyms: | 31-(pyrrolidin-1-yl)-5,15,25,30-tetraazaheptacyclo[27.2.2.1^{5,12}.1^{18,25}.0^{6,11}.0^{13,17}.0^{19,24}]pentatriaconta-1(31),6(11),7,9,12(35),13(17),18(34),19(24),20,22,29,32-dodecaene-14,16-dione | CHEMBL396327 |
Type | Small organic molecule |
Emp. Form. | C35H33N5O2 |
Mol. Mass. | 555.6688 |
SMILES | O=C1NC(=O)C2=C1c1cn(CCCc3ccc(CCCn4cc2c2ccccc42)c(n3)N2CCCC2)c2ccccc12 |c:5| |
Structure |
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