| Reaction Details |
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 | Report a problem with these data |
| Target | Glycogen synthase kinase-3 beta |
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| Ligand | BDBM50207805 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_454902 (CHEMBL886931) |
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| IC50 | 7±n/a nM |
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| Citation |  Zhang, HC; Boñaga, LV; Ye, H; Derian, CK; Damiano, BP; Maryanoff, BE Novel bis(indolyl)maleimide pyridinophanes that are potent, selective inhibitors of glycogen synthase kinase-3. Bioorg Med Chem Lett17:2863-8 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glycogen synthase kinase-3 beta |
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| Name: | Glycogen synthase kinase-3 beta |
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| Synonyms: | GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B |
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| Type: | Enzyme |
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| Mol. Mass.: | 46756.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49841 |
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| Residue: | 420 |
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| Sequence: | MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
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| BDBM50207805 |
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| n/a |
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| Name | BDBM50207805 |
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| Synonyms: | 20-(dimethylamino)-4,14,19,26-tetraazaheptacyclo[24.6.1.1^{7,14}.1^{18,22}.0^{2,6}.0^{8,13}.0^{27,32}]pentatriaconta-1(33),2(6),7(35),8(13),9,11,18,20,22(34),27(32),28,30-dodecaene-3,5-dione | CHEMBL247067 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H31N5O2 |
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| Mol. Mass. | 529.6315 |
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| SMILES | CN(C)c1cc2CCCn3cc(C4=C(C(=O)NC4=O)c4cn(CCCc(c2)n1)c1ccccc41)c1ccccc31 |t:12| |
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| Structure | 
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