| Reaction Details |
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 | Report a problem with these data |
| Target | Sphingosine 1-phosphate receptor 1 |
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| Ligand | BDBM50208900 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_455175 (CHEMBL887205) |
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| IC50 | 130±n/a nM |
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| Citation |  Nakamura, T; Yonesu, K; Mizuno, Y; Suzuki, C; Sakata, Y; Takuwa, Y; Nara, F; Satoh, S Synthesis and SAR studies of a novel class of S1P1 receptor antagonists. Bioorg Med Chem15:3548-64 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sphingosine 1-phosphate receptor 1 |
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| Name: | Sphingosine 1-phosphate receptor 1 |
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| Synonyms: | CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 42836.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21453 |
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| Residue: | 382 |
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| Sequence: | MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIM
GWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSH
PQKDEGDNPETIMSSGNVNSSS
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| BDBM50208900 |
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| n/a |
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| Name | BDBM50208900 |
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| Synonyms: | CHEMBL396365 | sodium 4-[(4-butoxyphenyl)thio]-20-[1-hydroxy-4-[(5-hydroxyundecyl)oxy]but-2-yn-1-yl]biphenyl-3-sulfonate |
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| Type | Small organic molecule |
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| Emp. Form. | C37H47O7S2 |
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| Mol. Mass. | 667.895 |
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| SMILES | CCCCOc1ccc(Sc2ccc(cc2S([O-])(=O)=O)-c2ccccc2C(O)C#CCOCCCCCCCCCCCO)cc1 |w:26.28| |
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| Structure | 
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