Reaction Details |
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Target | DNA polymerase catalytic subunit |
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Ligand | BDBM50210592 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_455453 (CHEMBL886229) |
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IC50 | 180±n/a nM |
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Citation | Schnute, ME; Anderson, DJ; Brideau, RJ; Ciske, FL; Collier, SA; Cudahy, MM; Eggen, M; Genin, MJ; Hopkins, TA; Judge, TM; Kim, EJ; Knechtel, ML; Nair, SK; Nieman, JA; Oien, NL; Scott, A; Tanis, SP; Vaillancourt, VA; Wathen, MW; Wieber, JL 2-Aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridines as broad-spectrum inhibitors of human herpesvirus polymerases. Bioorg Med Chem Lett17:3349-53 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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DNA polymerase catalytic subunit |
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Name: | DNA polymerase catalytic subunit |
Synonyms: | DNA polymerase | DPOL_HCMVA | HFLF2 | Human herpesvirus 5 DNA polymerase | UL54 |
Type: | Protein |
Mol. Mass.: | 137111.39 |
Organism: | Human cytomegalovirus (HCMV strain AD169) |
Description: | P08546 |
Residue: | 1242 |
Sequence: | MFFNPYLSGGVTGGAVAGGRRQRSQPGSAQGSGKRPPQKQFLQIVPRGVMFDGQTGLIKH
KTGRLPLMFYREIKHLLSHDMVWPCPWRETLVGRVVGPIRFHTYDQTDAVLFFDSPENVS
PRYRQHLVPSGNVLRFFGATEHGYSICVNVFGQRSYFYCEYSDTDRLREVIASVGELVPE
PRTPYAVSVTPATKTSIYGYGTRPVPDLQCVSISNWTMARKIGEYLLEQGFPVYEVRVDP
LTRLVIDRRITTFGWCSVNRYDWRQQGRASTCDIEVDCDVSDLVAVPDDSSWPRYRCLSF
DIECMSGEGGFPCAEKSDDIVIQISCVCYETGGNTAVDQGIPNGNDGRGCTSEGVIFGHS
GLHLFTIGTCGQVGPDVDVYEFPSEYELLLGFMLFFQRYAPAFVTGYNINSFDLKYILTR
LEYLYKVDSQRFCKLPTAQGGRFFLHSPAVGFKRQYAAAFPSASHNNPASTAATKVYIAG
SVVIDMYPVCMAKTNSPNYKLNTMAELYLRQRKDDLSYKDIPRCFVANAEGRAQVGRYCL
QDAVLVRDLFNTINFHYEAGAIARLAKIPLRRVIFDGQQIRIYTSLLDECACRDFILPNH
YSKGTTVPETNSVAVSPNAAIISTAAVPGDAGSVAAMFQMSPPLQSAPSSQDGVSPGSGS
NSSSSVGVFSVGSGSSGGVGVSNDNHGAGGTAAVSYQGATVFEPEVGYYNDPVAVFDFAS
LYPSIIMAHNLCYSTLLVPGGEYPVDPADVYSVTLENGVTHRFVRASVRVSVLSELLNKW
VSQRRAVRECMRECQDPVRRMLLDKEQMALKVTCNAFYGFTGVVNGMMPCLPIAASITRI
GRDMLERTARFIKDNFSEPCFLHNFFNQEDYVVGTREGDSEESSALPEGLETSSGGSNER
RVEARVIYGDTDSVFVRFRGLTPQALVARGPSLAHYVTACLFVEPVKLEFEKVFVSLMMI
CKKRYIGKVEGASGLSMKGVDLVRKTACEFVKGVTRDVLSLLFEDREVSEAAVRLSRLSL
DEVKKYGVPRGFWRILRRLVQARDDLYLHRVRVEDLVLSSVLSKDISLYRQSNLPHIAVI
KRLAARSEELPSVGDRVFYVLTAPGVRTAPQGSSDNGDSVTAGVVSRSDAIDGTDDDADG
GGVEESNRRGGEPAKKRARKPPSAVCNYEVAEDPSYVREHGVPIHADKYFEQVLKAVTNV
LSPVFPGGETARKDKFLHMVLPRRLHLEPAFLPYSVKAHECC
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BDBM50210592 |
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n/a |
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Name | BDBM50210592 |
Synonyms: | CHEMBL247956 | N-(4-chlorobenzyl)-2-(((2-(furan-2-yl)propyl)(methyl)amino)methyl)-4-oxo-7-propyl-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamide |
Type | Small organic molecule |
Emp. Form. | C27H30ClN3O3S |
Mol. Mass. | 512.063 |
SMILES | CCCn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(CN(C)CC(C)c3ccco3)sc12 |w:26.27| |
Structure |
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