| Reaction Details |
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 | Report a problem with these data |
| Target | DNA polymerase catalytic subunit |
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| Ligand | BDBM50210611 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_455453 (CHEMBL886229) |
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| IC50 | 100±n/a nM |
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| Citation |  Schnute, ME; Anderson, DJ; Brideau, RJ; Ciske, FL; Collier, SA; Cudahy, MM; Eggen, M; Genin, MJ; Hopkins, TA; Judge, TM; Kim, EJ; Knechtel, ML; Nair, SK; Nieman, JA; Oien, NL; Scott, A; Tanis, SP; Vaillancourt, VA; Wathen, MW; Wieber, JL 2-Aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridines as broad-spectrum inhibitors of human herpesvirus polymerases. Bioorg Med Chem Lett17:3349-53 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA polymerase catalytic subunit |
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| Name: | DNA polymerase catalytic subunit |
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| Synonyms: | DNA polymerase | DPOL_HCMVA | HFLF2 | Human herpesvirus 5 DNA polymerase | UL54 |
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| Type: | Protein |
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| Mol. Mass.: | 137111.39 |
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| Organism: | Human cytomegalovirus (HCMV strain AD169) |
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| Description: | P08546 |
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| Residue: | 1242 |
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| Sequence: | MFFNPYLSGGVTGGAVAGGRRQRSQPGSAQGSGKRPPQKQFLQIVPRGVMFDGQTGLIKH
KTGRLPLMFYREIKHLLSHDMVWPCPWRETLVGRVVGPIRFHTYDQTDAVLFFDSPENVS
PRYRQHLVPSGNVLRFFGATEHGYSICVNVFGQRSYFYCEYSDTDRLREVIASVGELVPE
PRTPYAVSVTPATKTSIYGYGTRPVPDLQCVSISNWTMARKIGEYLLEQGFPVYEVRVDP
LTRLVIDRRITTFGWCSVNRYDWRQQGRASTCDIEVDCDVSDLVAVPDDSSWPRYRCLSF
DIECMSGEGGFPCAEKSDDIVIQISCVCYETGGNTAVDQGIPNGNDGRGCTSEGVIFGHS
GLHLFTIGTCGQVGPDVDVYEFPSEYELLLGFMLFFQRYAPAFVTGYNINSFDLKYILTR
LEYLYKVDSQRFCKLPTAQGGRFFLHSPAVGFKRQYAAAFPSASHNNPASTAATKVYIAG
SVVIDMYPVCMAKTNSPNYKLNTMAELYLRQRKDDLSYKDIPRCFVANAEGRAQVGRYCL
QDAVLVRDLFNTINFHYEAGAIARLAKIPLRRVIFDGQQIRIYTSLLDECACRDFILPNH
YSKGTTVPETNSVAVSPNAAIISTAAVPGDAGSVAAMFQMSPPLQSAPSSQDGVSPGSGS
NSSSSVGVFSVGSGSSGGVGVSNDNHGAGGTAAVSYQGATVFEPEVGYYNDPVAVFDFAS
LYPSIIMAHNLCYSTLLVPGGEYPVDPADVYSVTLENGVTHRFVRASVRVSVLSELLNKW
VSQRRAVRECMRECQDPVRRMLLDKEQMALKVTCNAFYGFTGVVNGMMPCLPIAASITRI
GRDMLERTARFIKDNFSEPCFLHNFFNQEDYVVGTREGDSEESSALPEGLETSSGGSNER
RVEARVIYGDTDSVFVRFRGLTPQALVARGPSLAHYVTACLFVEPVKLEFEKVFVSLMMI
CKKRYIGKVEGASGLSMKGVDLVRKTACEFVKGVTRDVLSLLFEDREVSEAAVRLSRLSL
DEVKKYGVPRGFWRILRRLVQARDDLYLHRVRVEDLVLSSVLSKDISLYRQSNLPHIAVI
KRLAARSEELPSVGDRVFYVLTAPGVRTAPQGSSDNGDSVTAGVVSRSDAIDGTDDDADG
GGVEESNRRGGEPAKKRARKPPSAVCNYEVAEDPSYVREHGVPIHADKYFEQVLKAVTNV
LSPVFPGGETARKDKFLHMVLPRRLHLEPAFLPYSVKAHECC
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| BDBM50210611 |
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| n/a |
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| Name | BDBM50210611 |
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| Synonyms: | CHEMBL247751 | N-(4-chlorobenzyl)-2-(((2-hydroxy-2-(pyrimidin-2-yl)ethyl)(methyl)amino)methyl)-7-methyl-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamide |
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| Type | Small organic molecule |
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| Emp. Form. | C24H24ClN5O3S |
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| Mol. Mass. | 497.997 |
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| SMILES | CN(CC(O)c1ncccn1)Cc1cc2c(s1)n(C)cc(C(=O)NCc1ccc(Cl)cc1)c2=O |w:3.3| |
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| Structure | 
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