Ki Summary

Reaction Details

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Target

Muscarinic acetylcholine receptor M3

Ligand

BDBM50218056

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_457002 (CHEMBL923345)

43.6±n/a nM

Citation

Kumar, N; Kaur, K; Aeron, S; Dharmarajan, S; Silamkoti, AD; Mehta, A; Gupta, S; Chugh, A; Gupta, JB; Salman, M; Palle, VP; Cliffe, IA Synthesis and optimization of novel and selective muscarinic M(3) receptor antagonists. Bioorg Med Chem Lett17:5256-60 (2007) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Muscarinic acetylcholine receptor M3

Name:

Muscarinic acetylcholine receptor M3

Synonyms:

ACM3_RAT | Cholinergic, muscarinic M3 | Chrm-3 | Chrm3

Type:

Enzyme Catalytic Domain

Mol. Mass.:

66086.66

Organism:

RAT

Description:

Cholinergic, muscarinic M3 CHRM3 RAT::P08483

Residue:

589

Sequence:

MTLHSNSTTSPLFPNISSSWVHSPSEAGLPLGTVTQLGSYNISQETGNFSSNDTSSDPLG
GHTIWQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVIS
MNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRT
TKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFY
MPVTIMTILYWRIYKETEKRTKELAGLQASGTEAEAENFVHPTGSSRSCSSYELQQQGVK
RSSRRKYGRCHFWFTTKSWKPSAEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSET
RAIYSIVLKLPGHSSILNSTKLPSSDNLQVSNEDLGTVDVERNAHKLQAQKSMGDGDNCQ
KDFTKLPIQLESAVDTGKTSDTNSSADKTTATLPLSFKEATLAKRFALKTRSQITKRKRM
SLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNP
VCYALCNKTFRTTFKTLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQAL

BDBM50218056

n/a

Name

BDBM50218056

Synonyms:

CHEMBL249204 | methyl 4-(2-((1S,5R,6s)-6-((R)-2-cyclopentyl-2-hydroxy-2-phenylacetamido)-3-aza-bicyclo[3.1.0]hexan-3-yl)ethyl)benzoate

Type

Small organic molecule

Emp. Form.

C28H34N2O4

Mol. Mass.

462.5806

SMILES

COC(=O)c1ccc(CCN2C[C@H]3[C@@H](C2)[C@@H]3NC(=O)C(O)(C2CCCC2)c2ccccc2)cc1 |w:19.21|

Structure