Reaction Details |
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Target | 3-oxoacyl-[acyl-carrier-protein] synthase 3 |
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Ligand | BDBM50241313 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_457362 (CHEMBL940953) |
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IC50 | 75000±n/a nM |
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Citation | Bhowruth, V; Brown, AK; Senior, SJ; Snaith, JS; Besra, GS Synthesis and biological evaluation of a C5-biphenyl thiolactomycin library. Bioorg Med Chem Lett17:5643-6 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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3-oxoacyl-[acyl-carrier-protein] synthase 3 |
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Name: | 3-oxoacyl-[acyl-carrier-protein] synthase 3 |
Synonyms: | β-Ketoacyl-acyl carrier protein (ACP) synthase III (FabH) | 3-oxoacyl-[acyl-carrier-protein] synthase III | FABH_MYCTU | fabH |
Type: | Enzyme |
Mol. Mass.: | 34865.07 |
Organism: | Mycobacterium tuberculosis |
Description: | P9WNG3 |
Residue: | 335 |
Sequence: | MTEIATTSGARSVGLLSVGAYRPERVVTNDEICQHIDSSDEWIYTRTGIKTRRFAADDES
AASMATEACRRALSNAGLSAADIDGVIVTTNTHFLQTPPAAPMVAASLGAKGILGFDLSA
GCAGFGYALGAAADMIRGGGAATMLVVGTEKLSPTIDMYDRGNCFIFADGAAAVVVGETP
FQGIGPTVAGSDGEQADAIRQDIDWITFAQNPSGPRPFVRLEGPAVFRWAAFKMGDVGRR
AMDAAGVRPDQIDVFVPHQANSRINELLVKNLQLRPDAVVANDIEHTGNTSAASIPLAMA
ELLTTGAAKPGDLALLIGYGAGLSYAAQVVRMPKG
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BDBM50241313 |
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n/a |
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Name | BDBM50241313 |
Synonyms: | (5R)-4-hydroxy-3,5-dimethyl-5-[(1E)-2-methylbuta-1,3-dienyl]thiophen-2(5H)-one | (R)-(+)-Thiolactomycin | (R)-4-Hydroxy-3,5-dimethyl-5-((E)-2-methyl-buta-1,3-dienyl)-5H-thiophen-2-one | (R,E)-4-hydroxy-3,5-dimethyl-5-(2-methylbuta-1,3-dienyl)thiophen-2(5H)-one | 5R-Thiolactomycin | CHEMBL399043 | TLM analog, 1 |
Type | Small organic molecule |
Emp. Form. | C11H14O2S |
Mol. Mass. | 210.293 |
SMILES | CC1C(=O)S[C@](C)(\C=C(/C)C=C)C1=O |r| |
Structure |
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