| Reaction Details |
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 | Report a problem with these data |
| Target | 3-oxoacyl-[acyl-carrier-protein] synthase 3 |
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| Ligand | BDBM50220624 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_457362 (CHEMBL940953) |
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| IC50 | 4000±n/a nM |
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| Citation |  Bhowruth, V; Brown, AK; Senior, SJ; Snaith, JS; Besra, GS Synthesis and biological evaluation of a C5-biphenyl thiolactomycin library. Bioorg Med Chem Lett17:5643-6 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 3-oxoacyl-[acyl-carrier-protein] synthase 3 |
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| Name: | 3-oxoacyl-[acyl-carrier-protein] synthase 3 |
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| Synonyms: | β-Ketoacyl-acyl carrier protein (ACP) synthase III (FabH) | 3-oxoacyl-[acyl-carrier-protein] synthase III | FABH_MYCTU | fabH |
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| Type: | Enzyme |
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| Mol. Mass.: | 34865.07 |
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| Organism: | Mycobacterium tuberculosis |
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| Description: | P9WNG3 |
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| Residue: | 335 |
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| Sequence: | MTEIATTSGARSVGLLSVGAYRPERVVTNDEICQHIDSSDEWIYTRTGIKTRRFAADDES
AASMATEACRRALSNAGLSAADIDGVIVTTNTHFLQTPPAAPMVAASLGAKGILGFDLSA
GCAGFGYALGAAADMIRGGGAATMLVVGTEKLSPTIDMYDRGNCFIFADGAAAVVVGETP
FQGIGPTVAGSDGEQADAIRQDIDWITFAQNPSGPRPFVRLEGPAVFRWAAFKMGDVGRR
AMDAAGVRPDQIDVFVPHQANSRINELLVKNLQLRPDAVVANDIEHTGNTSAASIPLAMA
ELLTTGAAKPGDLALLIGYGAGLSYAAQVVRMPKG
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| BDBM50220624 |
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| n/a |
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| Name | BDBM50220624 |
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| Synonyms: | 4'-(3-hydroxy-2,4-dimethyl-5-oxo-2,5-dihydro-thiophen-2-ylmethyl)-biphenyl-4-carboxylic acid amide | CHEMBL399477 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H19NO3S |
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| Mol. Mass. | 353.435 |
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| SMILES | CC1C(=O)SC(C)(Cc2ccc(cc2)-c2ccc(cc2)C(N)=O)C1=O |
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| Structure | 
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