Reaction Details |
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Target | Progesterone receptor |
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Ligand | BDBM50222091 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_457750 (CHEMBL924027) |
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IC50 | 0.59±n/a nM |
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Citation | Jin, C; Manikumar, G; Kepler, JA; Cook, CE; Allan, GF; Kiddoe, M; Bhattacharjee, S; Linton, O; Lundeen, SG; Sui, Z Synthesis and identification of novel 11beta-aryl-4',5'-dihydrospiro[estra-4,9-diene-17beta,4'-oxazole] analogs with dissociated antiprogesterone activities. Bioorg Med Chem Lett17:5754-7 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Progesterone receptor |
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Name: | Progesterone receptor |
Synonyms: | NR3C3 | Nuclear receptor subfamily 3 group C member 3 | PGR | PR | PRGR_HUMAN | progesterone |
Type: | Protein |
Mol. Mass.: | 98979.52 |
Organism: | Homo sapiens (Human) |
Description: | P06401 |
Residue: | 933 |
Sequence: | MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEVSAIPISLDGLLF
PRPCQGQDPSDEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLA
PSGPGQSQPSPPACEVTSSWCLFGPELPEDPPAAPATQRVLSPLMSRSGCKVGDSSGTAA
AHKVLPRGLSPARQLLLPASESPHWSGAPVKPSPQAAAVEVEEEDGSESEESAGPLLKGK
PRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPGRSPLATTV
MDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAASAFAPPRSSPCASSTPVAVGDFPD
CAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLG
PPPPLPPRATPSRPGEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPC
KAPGASGCLLPRDGLPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPP
YLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHN
YLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPV
GVPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQ
LGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAP
DLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQ
FEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRA
LSVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK
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BDBM50222091 |
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n/a |
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Name | BDBM50222091 |
Synonyms: | (3S,10'S,11'S,15'S,17'R)-17'-(4-acetylphenyl)-5,15'-dimethyl-2-methylidene-2H-spiro[1,4-oxazole-3,14'-tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecane]-1',6'-dien-5'-one | CHEMBL400582 |
Type | Small organic molecule |
Emp. Form. | C30H33NO3 |
Mol. Mass. | 455.5879 |
SMILES | CC(=O)c1ccc(cc1)[C@H]1C[C@@]2(C)[C@@H](CC[C@]22N=C(C)OC2=C)[C@@H]2CCC3=CC(=O)CCC3=C12 |t:19,29,36| |
Structure |
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