| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Carbonic anhydrase 5B, mitochondrial |
|---|
| Ligand | BDBM10884 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_459054 (CHEMBL925146) |
|---|
| Ki | 33±n/a nM |
|---|
| Citation |  Supuran, CT; Scozzafava, A Carbonic anhydrases as targets for medicinal chemistry. Bioorg Med Chem15:4336-50 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Carbonic anhydrase 5B, mitochondrial |
|---|
| Name: | Carbonic anhydrase 5B, mitochondrial |
|---|
| Synonyms: | CA-VB | CA5B | CAH5B_HUMAN | Carbonate dehydratase VB | Carbonic Anhydrase VB | Carbonic anhydrase 5B (CA VB) | Carbonic anhydrase 5B, mitochondrial | Carbonic anhydrase 5B, mitochondrial precursor | Carbonic anhydrase V | Carbonic anhydrase VB (CA VB) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 36440.83 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Human (cloned) isozyme |
|---|
| Residue: | 317 |
|---|
| Sequence: | MVVMNSLRVILQASPGKLLWRKFQIPRFMPARPCSLYTCTYKTRNRALHPLWESVDLVPG
GDRQSPINIRWRDSVYDPGLKPLTISYDPATCLHVWNNGYSFLVEFEDSTDKSVIKGGPL
EHNYRLKQFHFHWGAIDAWGSEHTVDSKCFPAELHLVHWNAVRFENFEDAALEENGLAVI
GVFLKLGKHHKELQKLVDTLPSIKHKDALVEFGSFDPSCLMPTCPDYWTYSGSLTTPPLS
ESVTWIIKKQPVEVDHDQLEQFRTLLFTSEGEKEKRMVDNFRPLQPLMNRTVRSSFRHDY
VLNVQAKPKPATSQATP
|
|
|
|---|
| BDBM10884 |
|---|
| n/a |
|---|
| Name | BDBM10884 |
|---|
| Synonyms: | (2S,4S)-4-(ethylamino)-2-methyl-1,1-dioxo-2H,3H,4H-1,7-thieno[2,3-b]thiopyran-6-sulfonamide | Dorzolamide (DRZ) | Dorzolamide (DZA) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C10H16N2O4S3 |
|---|
| Mol. Mass. | 324.44 |
|---|
| SMILES | CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
