| Reaction Details |
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 | Report a problem with these data |
| Target | Lanosterol synthase |
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| Ligand | BDBM50055641 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_459088 (CHEMBL925174) |
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| IC50 | 50±n/a nM |
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| Citation |  Jain, KS; Kathiravan, MK; Somani, RS; Shishoo, CJ The biology and chemistry of hyperlipidemia. Bioorg Med Chem15:4674-99 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lanosterol synthase |
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| Name: | Lanosterol synthase |
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| Synonyms: | LSS_RAT | Lss | Osc |
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| Type: | PROTEIN |
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| Mol. Mass.: | 83302.12 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_12083 |
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| Residue: | 733 |
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| Sequence: | MTEGTCLRRRGGPYKTEPATDLTRWRLHNELGRQRWTYYQAEEDPGREQTGLEAHSLGLD
TTSYFKNLPKAQTAHEGALNGVTFYAKLQAEDGHWAGDYGGPLFLLPGLLITCHIAHIPL
PAGYREEMVRYLRSVQLPDGGWGLHIEDKSTVFGTALSYVSLRILGIGPDDPDLVRARNI
LHKKGGAVAIPSWGKFWLAVLNVYSWEGINTLFPEMWLLPEWFPAHPSTLWCHCRQVYLP
MSYCYATRLSASEDPLVQSLRQELYVEDYASIDWPAQKNNVCPDDMYTPHSWLLHVVYGL
LNLYERFHSTSLRKWAIQLLYEHVAADDRFTKCISIGPISKTVNMLIRWSVDGPSSPAFQ
EHVSRIKDYLWLGLDGMKMQGTNGSQTWDTSFAVQALLEAGAHRRPEFLPCLQKAHEFLR
LSQVPDNNPDYQKYYRHMHKGGFPFSTLDCGWIVADCTAEALKAVLLLQERCPSITEHVP
RERLYDAVAVLLSMRNSDGGFATYETKRGGYLLELLNPSEVFGDIMIDYTYVECTSAVMQ
ALRHFREYFPDHRATESRETLNQGLDFCRKKQRADGSWEGSWGVCFTYGTWFGLEAFACM
GHIYQNRTACAEVAQACHFLLSRQMADGGWGEDFESCEQRRYVQSAGSQVHSTCWALLGL
MAVRHPDISAQERGIRCLLGKQLPNGDWPQENISGVFNKSCAISYTNYRNIFPIWALGRF
SSLYPDNTLAGHI
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| BDBM50055641 |
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| n/a |
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| Name | BDBM50055641 |
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| Synonyms: | 2,2-dimethyl-3-((3E,7E,11E)-3,7,12-trimethyl-14-(6-methylhept-5-en-2-ylthio)tetradeca-3,7,11-trienyl)oxirane | 3-[(3E,7E,11E)-14-(1,5-Dimethyl-hex-4-enylsulfanyl)-3,7,12-trimethyl-tetradeca-3,7,11-trienyl]-2,2-dimethyl-oxirane | CHEMBL64905 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H50OS |
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| Mol. Mass. | 446.772 |
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| SMILES | [#6]-[#6](-[#6]-[#6]\[#6]=[#6](\[#6])-[#6])-[#16]-[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]-[#6]1-[#8]C1([#6])[#6] |
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| Structure | 
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