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TargetMelanocyte-stimulating hormone receptor
LigandBDBM50230818
Substrate/Competitorn/a
Meas. Tech.ChEMBL_460495 (CHEMBL926575)
IC50>10000±n/a nM
Citation Mayorov, AVCai, MPalmer, ESDedek, MMCain, JPVan Scoy, ARTan, BVagner, JTrivedi, DHruby, VJ Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 receptor. J Med Chem51:187-95 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Melanocyte-stimulating hormone receptor
Name:Melanocyte-stimulating hormone receptor
Synonyms:MC1-R | MC1R | MSH-R | MSHR | MSHR_HUMAN | Melanocortin MC1 | Melanocortin receptor (M1 and M4) | Melanocortin receptor 1 (MC-1) | Melanocortin receptor 1 (MC1-R) | Melanocortin receptor 1 (MC1R)
Type:Enzyme
Mol. Mass.:34717.23
Organism:Homo sapiens (Human)
Description:Q01726
Residue:317
Sequence:
MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVV
ATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVI
DVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFI
AYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGA
VTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAF
HSQELRRTLKEVLTCSW
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  Blast E-value cutoff:
BDBM50230818
n/a
NameBDBM50230818
Synonyms:CHEMBL413043 | c[CO-2,6-pyridine-CO-D-Phe-Arg-Trp-Lys]-NH2
TypeSmall organic molecule
Emp. Form.C39H47N11O6
Mol. Mass.765.8606
SMILESNC(N)=NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)c2cccc(n2)C(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)C(N)=O |wU:7.6,39.41,wD:11.11,35.57,(25.77,6.84,;24.43,6.08,;23.09,6.84,;24.43,4.53,;23.09,3.76,;23.09,2.22,;21.76,1.45,;21.76,-.09,;20.42,-.87,;19.08,-.09,;19.08,1.45,;17.75,-.87,;16.42,-.09,;16.42,1.45,;17.75,2.21,;17.75,3.75,;16.42,4.53,;15.08,3.74,;15.09,2.21,;17.75,-2.41,;16.42,-3.18,;15.08,-2.41,;16.42,-4.72,;17.74,-5.49,;17.75,-7.03,;16.41,-7.8,;15.07,-7.03,;15.08,-5.49,;13.9,-7.78,;12.21,-7.8,;17.78,-10.11,;19.11,-9.34,;20.44,-10.11,;21.77,-9.34,;21.77,-7.81,;23.09,-7.04,;23.09,-5.5,;24.43,-4.72,;25.77,-5.5,;24.43,-3.18,;25.77,-2.41,;27.1,-3.18,;27.27,-4.71,;28.78,-5.03,;29.54,-3.7,;31.05,-3.38,;31.52,-1.92,;30.5,-.78,;29,-1.09,;28.52,-2.55,;23.09,-2.41,;23.09,-.87,;24.43,-.09,;24.42,-7.81,;25.75,-7.04,;24.42,-9.34,)|
Structure
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