Reaction Details | |||
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Target | Melanocyte-stimulating hormone receptor | ||
Ligand | BDBM50230818 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_460495 (CHEMBL926575) | ||
IC50 | >10000±n/a nM | ||
Citation | Mayorov, AV; Cai, M; Palmer, ES; Dedek, MM; Cain, JP; Van Scoy, AR; Tan, B; Vagner, J; Trivedi, D; Hruby, VJ Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 receptor. J Med Chem51:187-95 (2008) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Melanocyte-stimulating hormone receptor | |||
Name: | Melanocyte-stimulating hormone receptor | ||
Synonyms: | MC1-R | MC1R | MSH-R | MSHR | MSHR_HUMAN | Melanocortin MC1 | Melanocortin receptor (M1 and M4) | Melanocortin receptor 1 (MC-1) | Melanocortin receptor 1 (MC1-R) | Melanocortin receptor 1 (MC1R) | ||
Type: | Enzyme | ||
Mol. Mass.: | 34717.23 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q01726 | ||
Residue: | 317 | ||
Sequence: |
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BDBM50230818 | |||
n/a | |||
Name | BDBM50230818 | ||
Synonyms: | CHEMBL413043 | c[CO-2,6-pyridine-CO-D-Phe-Arg-Trp-Lys]-NH2 | ||
Type | Small organic molecule | ||
Emp. Form. | C39H47N11O6 | ||
Mol. Mass. | 765.8606 | ||
SMILES | NC(N)=NCCC[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)c2cccc(n2)C(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)C(N)=O |wU:7.6,39.41,wD:11.11,35.57,(25.77,6.84,;24.43,6.08,;23.09,6.84,;24.43,4.53,;23.09,3.76,;23.09,2.22,;21.76,1.45,;21.76,-.09,;20.42,-.87,;19.08,-.09,;19.08,1.45,;17.75,-.87,;16.42,-.09,;16.42,1.45,;17.75,2.21,;17.75,3.75,;16.42,4.53,;15.08,3.74,;15.09,2.21,;17.75,-2.41,;16.42,-3.18,;15.08,-2.41,;16.42,-4.72,;17.74,-5.49,;17.75,-7.03,;16.41,-7.8,;15.07,-7.03,;15.08,-5.49,;13.9,-7.78,;12.21,-7.8,;17.78,-10.11,;19.11,-9.34,;20.44,-10.11,;21.77,-9.34,;21.77,-7.81,;23.09,-7.04,;23.09,-5.5,;24.43,-4.72,;25.77,-5.5,;24.43,-3.18,;25.77,-2.41,;27.1,-3.18,;27.27,-4.71,;28.78,-5.03,;29.54,-3.7,;31.05,-3.38,;31.52,-1.92,;30.5,-.78,;29,-1.09,;28.52,-2.55,;23.09,-2.41,;23.09,-.87,;24.43,-.09,;24.42,-7.81,;25.75,-7.04,;24.42,-9.34,)| | ||
Structure |