Ki Summary

Reaction Details

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Target

Melanocortin receptor 4

Ligand

BDBM50230814

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_460497 (CHEMBL926577)

IC50

430±n/a nM

Citation

Mayorov, AV; Cai, M; Palmer, ES; Dedek, MM; Cain, JP; Van Scoy, AR; Tan, B; Vagner, J; Trivedi, D; Hruby, VJ Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 receptor. J Med Chem51:187-95 (2008) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Melanocortin receptor 4

Name:

Melanocortin receptor 4

Synonyms:

Type:

Enzyme

Mol. Mass.:

36949.50

Organism:

Homo sapiens (Human)

Description:

P32245

Residue:

332

Sequence:

MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY

BDBM50230814

n/a

Name

BDBM50230814

Synonyms:

CHEMBL253788 | c[CO-o-C6H4-CO-Pro-D-Nal(2)-Arg-Trp-Lys]-NH2

Type

Small organic molecule

Emp. Form.

C49H57N11O7

Mol. Mass.

912.0464

SMILES

NC(N)=NCCC[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)c2ccccc2C(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)C(N)=O |wU:26.32,50.54,wD:7.6,11.11,46.70,(7.14,-23.43,;5.81,-22.67,;4.47,-23.45,;5.8,-21.13,;4.46,-20.37,;4.46,-18.83,;3.12,-18.06,;3.11,-16.52,;1.78,-15.76,;.44,-16.53,;.45,-18.07,;-.89,-15.77,;-.9,-14.23,;-2.24,-13.46,;-2.24,-11.91,;-3.58,-11.15,;-4.91,-11.93,;-6.25,-11.16,;-7.57,-11.93,;-7.58,-13.48,;-6.25,-14.25,;-4.91,-13.47,;-3.57,-14.24,;-2.22,-16.55,;-2.24,-18.07,;-.9,-18.86,;-3.57,-18.84,;-4.98,-18.22,;-6.01,-19.36,;-5.24,-20.7,;-3.73,-20.38,;-2.59,-21.41,;-1.13,-20.94,;-2.91,-22.92,;-4.38,-23.39,;-4.7,-24.89,;-3.55,-25.93,;-2.08,-25.44,;-1.77,-23.94,;-.3,-23.46,;.01,-21.95,;.84,-24.49,;13,-24.43,;11.14,-22.65,;11.13,-21.11,;9.8,-20.34,;9.79,-18.8,;8.45,-18.04,;8.45,-16.5,;9.78,-15.72,;7.11,-15.73,;7.1,-14.19,;8.43,-13.42,;9.84,-14.03,;10.86,-12.88,;10.08,-11.56,;10.55,-10.11,;9.53,-8.97,;8.02,-9.3,;7.56,-10.75,;8.58,-11.88,;5.78,-16.51,;4.44,-15.75,;4.44,-14.21,;11.12,-18.03,;11.11,-16.49,;12.46,-18.79,)|

Structure