Reaction Details |
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Target | Disintegrin and metalloproteinase domain-containing protein 17 |
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Ligand | BDBM50227856 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_461588 (CHEMBL927611) |
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Ki | 0.15±n/a nM |
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Citation | Duan, JJ; Chen, L; Lu, Z; Xue, CB; Liu, RQ; Covington, MB; Qian, M; Wasserman, ZR; Vaddi, K; Christ, DD; Trzaskos, JM; Newton, RC; Decicco, CP Discovery of beta-benzamido hydroxamic acids as potent, selective, and orally bioavailable TACE inhibitors. Bioorg Med Chem Lett18:241-6 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Disintegrin and metalloproteinase domain-containing protein 17 |
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Name: | Disintegrin and metalloproteinase domain-containing protein 17 |
Synonyms: | A disintegrin and metalloproteinase domain 17 | ADA17_PIG | ADAM 17 | ADAM17 | Snake venom-like protease | TACE | TNF-alpha-Converting Enzyme |
Type: | Metalloprotease |
Mol. Mass.: | 12197.99 |
Organism: | Sus scrofa (pig) |
Description: | Partially purified TACE was obtained from porcine spleen. |
Residue: | 112 |
Sequence: | MLREQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPIGK
KNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNE
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BDBM50227856 |
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n/a |
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Name | BDBM50227856 |
Synonyms: | (3R,4R)-N-hydroxy-4-(4-((2-methylquinolin-4-yl)methoxy)benzamido)-tetrahydro-2H-pyran-3-carboxamide | (3R,4R)-N-hydroxy-4-(4-((2-methylquinolin-4-yl)methoxy)benzamido)tetrahydro-2H-pyran-3-carboxamide | CHEMBL252893 |
Type | Small organic molecule |
Emp. Form. | C24H25N3O5 |
Mol. Mass. | 435.4724 |
SMILES | Cc1cc(COc2ccc(cc2)C(=O)N[C@@H]2CCOC[C@@H]2C(=O)NO)c2ccccc2n1 |r| |
Structure |
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