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TargetCoagulation factor X
LigandBDBM50228918
Substrate/Competitorn/a
Meas. Tech.ChEMBL_461701 (CHEMBL927722)
Ki 22±n/a nM
Citation Varnes, JGWacker, DAPinto, DJOrwat, MJTheroff, JPWells, BGalemo, RALuettgen, JMKnabb, RMBai, SHe, KLam, PYWexler, RR Structure-activity relationship and pharmacokinetic profile of 5-ketopyrazole factor Xa inhibitors. Bioorg Med Chem Lett18:749-54 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor X
Name:Coagulation factor X
Synonyms:Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:Enzyme
Mol. Mass.:54726.60
Organism:Homo sapiens (Human)
Description:n/a
Residue:488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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  Blast E-value cutoff:
BDBM50228918
n/a
NameBDBM50228918
Synonyms:4'-{2-[2-(3-amino-benzo[d]isoxazol-5-yl)-5-trifluoromethyl-2H-pyrazol-3-yl]-1-methyl-2-oxo-ethyl}-biphenyl-2-sulfonic acid amide | CHEMBL404286
TypeSmall organic molecule
Emp. Form.C26H20F3N5O4S
Mol. Mass.555.528
SMILESCC(C(=O)c1cc(nn1-c1ccc2onc(N)c2c1)C(F)(F)F)c1ccc(cc1)-c1ccccc1S(N)(=O)=O
Structure
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