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TargetCathepsin K
LigandBDBM50255753
Substrate/Competitorn/a
Meas. Tech.ChEMBL_462255 (CHEMBL945089)
IC50 1±n/a nM
Citation Gauthier, JYChauret, NCromlish, WDesmarais, SDuong, le TFalgueyret, JPKimmel, DBLamontagne, SLéger, SLeRiche, TLi, CSMassé, FMcKay, DJNicoll-Griffith, DAOballa, RMPalmer, JTPercival, MDRiendeau, DRobichaud, JRodan, GARodan, SBSeto, CThérien, MTruong, VLVenuti, MCWesolowski, GYoung, RNZamboni, RBlack, WC The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K. Bioorg Med Chem Lett18:923-8 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cathepsin K
Name:Cathepsin K
Synonyms:CATK_RABIT | CTSK
Type:Enzyme
Mol. Mass.:36879.51
Organism:Oryctolagus cuniculus (rabbit)
Description:n/a
Residue:329
Sequence:
MWGLKVLLLPVVSFALHPEEILDTQWELWKKTYSKQYNSKVDEISRRLIWEKNLKHISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPPSRSHSNDTLYIPDWEGRTPDSID
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENYGCGGG
YMTNAFQYVQRNRGIDSEDAYPYVGQDESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDENCSSDNVNHAVLAVGYGIQKGNKHWIIKNSWGE
SWGNKGYILMARNKNNACGIANLASFPKM
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50255753
n/a
NameBDBM50255753
Synonyms:CHEMBL481611 | MK-0822 | Odanacatib
TypeSmall organic molecule
Emp. Form.C25H27F4N3O3S
Mol. Mass.525.559
SMILESCC(C)(F)C[C@H](N[C@@H](c1ccc(cc1)-c1ccc(cc1)S(C)(=O)=O)C(F)(F)F)C(=O)NC1(CC1)C#N |r|
Structure
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