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TargetCathepsin S
LigandBDBM19778
Substrate/Competitorn/a
Meas. Tech.ChEMBL_462259
IC50 8±n/a nM
Citation Gauthier JYChauret NCromlish WDesmarais SDuong le TFalgueyret JPKimmel DBLamontagne SLéger SLeRiche TLi CSMassé FMcKay DJNicoll-Griffith DAOballa RMPalmer JTPercival MDRiendeau DRobichaud JRodan GARodan SBSeto CThérien MTruong VLVenuti MCWesolowski GYoung RNZamboni RBlack WC The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K. Bioorg Med Chem Lett 18:923-8 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cathepsin S
Name:Cathepsin S
Synonyms:CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:Protein
Mol. Mass.:37507.38
Organism:Homo sapiens (Human)
Description:P25774
Residue:331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVM
LHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVD
WREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGC
NGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKE
AVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSW
GHNFGEEGYIRMARNKGNHCGIASFPSYPEI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM19778
n/a
NameBDBM19778
Synonyms:(2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4S,7R)-7-methyl-3-oxo-1-(pyridine-2-sulfonyl)azepan-4-yl]pentanamide | Azepan-3-one compound 10 | CHEMBL203665
TypeSmall organic molecule
Emp. Form.C27H32N4O6S
Mol. Mass.540.631
SMILESCC(C)C[C@H](NC(=O)c1cc2ccccc2o1)C(=O)N[C@H]1CC[C@@H](C)N(CC1=O)S(=O)(=O)c1ccccn1 |r|
Structure
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