| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin Z |
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| Ligand | BDBM50255753 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_462253 (CHEMBL945087) |
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| IC50 | >10±n/a nM |
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| Citation |  Gauthier, JY; Chauret, N; Cromlish, W; Desmarais, S; Duong, le T; Falgueyret, JP; Kimmel, DB; Lamontagne, S; Léger, S; LeRiche, T; Li, CS; Massé, F; McKay, DJ; Nicoll-Griffith, DA; Oballa, RM; Palmer, JT; Percival, MD; Riendeau, D; Robichaud, J; Rodan, GA; Rodan, SB; Seto, C; Thérien, M; Truong, VL; Venuti, MC; Wesolowski, G; Young, RN; Zamboni, R; Black, WC The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K. Bioorg Med Chem Lett18:923-8 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin Z |
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| Name: | Cathepsin Z |
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| Synonyms: | CATZ_HUMAN | CTSZ | Cathepsin P | Cathepsin X |
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| Type: | PROTEIN |
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| Mol. Mass.: | 33870.59 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_595889 |
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| Residue: | 303 |
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| Sequence: | MARRGPGWRPLLLLVLLAGAAQGGLYFRRGQTCYRPLRGDGLAPLGRSTYPRPHEYLSPA
DLPKSWDWRNVDGVNYASITRNQHIPQYCGSCWAHASTSAMADRINIKRKGAWPSTLLSV
QNVIDCGNAGSCEGGNDLSVWDYAHQHGIPDETCNNYQAKDQECDKFNQCGTCNEFKECH
AIRNYTLWRVGDYGSLSGREKMMAEIYANGPISCGIMATERLANYTGGIYAEYQDTTYIN
HVVSVAGWGISDGTEYWIVRNSWGEPWGERGWLRIVTSTYKDGKGARYNLAIEEHCTFGD
PIV
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| BDBM50255753 |
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| n/a |
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| Name | BDBM50255753 |
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| Synonyms: | CHEMBL481611 | MK-0822 | Odanacatib |
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| Type | Small organic molecule |
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| Emp. Form. | C25H27F4N3O3S |
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| Mol. Mass. | 525.559 |
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| SMILES | CC(C)(F)C[C@H](N[C@@H](c1ccc(cc1)-c1ccc(cc1)S(C)(=O)=O)C(F)(F)F)C(=O)NC1(CC1)C#N |r| |
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| Structure | 
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