| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neuraminidase |
|---|
| Ligand | BDBM50233740 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_462436 (CHEMBL927252) |
|---|
| Ki | 12±n/a nM |
|---|
| Citation |  Krueger, AC; Xu, Y; Kati, WM; Kempf, DJ; Maring, CJ; McDaniel, KF; Molla, A; Montgomery, D; Kohlbrenner, WE Synthesis of potent pyrrolidine influenza neuraminidase inhibitors. Bioorg Med Chem Lett18:1692-5 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Neuraminidase |
|---|
| Name: | Neuraminidase |
|---|
| Synonyms: | Influenza B Virus Neuraminidase | NA | NRAM_INBLE | Neuraminidase | Neuraminidase B |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 51446.67 |
|---|
| Organism: | Influenza B virus (B/Lee/40) |
|---|
| Description: | n/a |
|---|
| Residue: | 466 |
|---|
| Sequence: | MLPSTVQTLTLLLTSGGVLLSLYVSASLSYLLYSDVLLKFSSTKTTAPTMSLECTNASNA
QTVNHSATKEMTFPPPEPEWTYPRLSCQGSTFQKALLISPHRFGEIKGNSAPLIIREPFV
ACGPKECRHFALTHYAAQPGGYYNGTRKDRNKLRHLVSVKLGKIPTVENSIFHMAAWSGS
ACHDGREWTYIGVDGPDNDALVKIKYGEAYTDTYHSYAHNILRTQESACNCIGGDCYLMI
TDGSASGISKCRFLKIREGRIIKEILPTGRVEHTEECTCGFASNKTIECACRDNSYTAKR
PFVKLNVETDTAEIRLMCTKTYLDTPRPDDGSIAGPCESNGDKWLGGIKGGFVHQRMASK
IGRWYSRTMSKTNRMGMELYVKYDGDPWTDSDALTLSGVMVSIEEPGWYSFGFEIKDKKC
DVPCIGIEMVHDGGKDTWHSAATAIYCLMGSGQLLWDTVTGVDMAL
|
|
|
|---|
| BDBM50233740 |
|---|
| n/a |
|---|
| Name | BDBM50233740 |
|---|
| Synonyms: | (2R,4S,5R)-5-((1R,2S)-1-acetamido-2-hydroxyhexyl)-4-(prop-1-enyl)pyrrolidine-2-carboxylic acid | CHEMBL400495 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H28N2O4 |
|---|
| Mol. Mass. | 312.4045 |
|---|
| SMILES | CCCC[C@H](O)[C@H](NC(C)=O)[C@@H]1N[C@H](C[C@H]1\C=C/C)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
