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TargetC-X-C chemokine receptor type 2
LigandBDBM50236311
Substrate/Competitorn/a
Meas. Tech.ChEMBL_462970 (CHEMBL928888)
IC50 170±n/a nM
Citation Winters, MPCrysler, CSubasinghe, NRyan, DLeong, LZhao, SDonatelli, RYurkow, EMazzulla, MBoczon, LManthey, CLMolloy, CRaymond, HMurray, LMcAlonan, LTomczuk, B Carboxylic acid bioisosteres acylsulfonamides, acylsulfamides, and sulfonylureas as novel antagonists of the CXCR2 receptor. Bioorg Med Chem Lett18:1926-30 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
C-X-C chemokine receptor type 2
Name:C-X-C chemokine receptor type 2
Synonyms:C-X-C chemokine receptor type 2 (CXCR-2) | C-X-C chemokine receptor type 2 (CXCR2) | CD_antigen=CD182 | CDw128b | CXCR-2 | CXCR2 | CXCR2_HUMAN | Chemokine receptor type 2 (CXCR2) | GRO/MGSA receptor | High affinity interleukin-8 receptor B | IL-8 receptor type 2 | IL-8R B | IL8RB | Interleukin-8 receptor B
Type:Protein
Mol. Mass.:40767.88
Organism:Homo sapiens (Human)
Description:P25025
Residue:360
Sequence:
MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFL
LSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCK
VVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPV
LLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFK
AHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATE
ILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
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BDBM50236311
n/a
NameBDBM50236311
Synonyms:4-(5-bromo-2-(4-fluorophenyl)-1H-indol-3-yl)-N-(methylsulfonyl)butanamide | CHEMBL255481
TypeSmall organic molecule
Emp. Form.C19H18BrFN2O3S
Mol. Mass.453.325
SMILESCS(=O)(=O)NC(=O)CCCc1c([nH]c2ccc(Br)cc12)-c1ccc(F)cc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: