| Reaction Details |
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 | Report a problem with these data |
| Target | C-X-C chemokine receptor type 2 |
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| Ligand | BDBM50236316 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_462970 (CHEMBL928888) |
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| IC50 | 160±n/a nM |
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| Citation |  Winters, MP; Crysler, C; Subasinghe, N; Ryan, D; Leong, L; Zhao, S; Donatelli, R; Yurkow, E; Mazzulla, M; Boczon, L; Manthey, CL; Molloy, C; Raymond, H; Murray, L; McAlonan, L; Tomczuk, B Carboxylic acid bioisosteres acylsulfonamides, acylsulfamides, and sulfonylureas as novel antagonists of the CXCR2 receptor. Bioorg Med Chem Lett18:1926-30 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-X-C chemokine receptor type 2 |
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| Name: | C-X-C chemokine receptor type 2 |
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| Synonyms: | C-X-C chemokine receptor type 2 (CXCR-2) | C-X-C chemokine receptor type 2 (CXCR2) | CD_antigen=CD182 | CDw128b | CXCR-2 | CXCR2 | CXCR2_HUMAN | Chemokine receptor type 2 (CXCR2) | GRO/MGSA receptor | High affinity interleukin-8 receptor B | IL-8 receptor type 2 | IL-8R B | IL8RB | Interleukin-8 receptor B |
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| Type: | Protein |
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| Mol. Mass.: | 40767.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25025 |
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| Residue: | 360 |
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| Sequence: | MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFL
LSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCK
VVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPV
LLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFK
AHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATE
ILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
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| BDBM50236316 |
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| n/a |
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| Name | BDBM50236316 |
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| Synonyms: | 4-(5-cyano-2-(4-fluorophenyl)-6-methoxy-1H-indol-3-yl)-N-(methylsulfonyl)butanamide | CHEMBL404088 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H20FN3O4S |
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| Mol. Mass. | 429.465 |
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| SMILES | COc1cc2[nH]c(c(CCCC(=O)NS(C)(=O)=O)c2cc1C#N)-c1ccc(F)cc1 |
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| Structure | 
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