| Reaction Details |
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 | Report a problem with these data |
| Target | B1 bradykinin receptor |
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| Ligand | BDBM50229295 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_463210 (CHEMBL947207) |
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| IC50 | 4.47±n/a nM |
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| Citation |  Wood, MR; Schirripa, KM; Kim, JJ; Kuduk, SD; Chang, RK; Di Marco, CN; DiPardo, RM; Wan, BL; Murphy, KL; Ransom, RW; Chang, RS; Holahan, MA; Cook, JJ; Lemaire, W; Mosser, SD; Bednar, RA; Tang, C; Prueksaritanont, T; Wallace, AA; Mei, Q; Yu, J; Bohn, DL; Clayton, FC; Adarayn, ED; Sitko, GR; Leonard, YM; Freidinger, RM; Pettibone, DJ; Bock, MG Alpha-hydroxy amides as a novel class of bradykinin B1 selective antagonists. Bioorg Med Chem Lett18:716-20 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| B1 bradykinin receptor |
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| Name: | B1 bradykinin receptor |
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| Synonyms: | B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 40508.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P46663 |
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| Residue: | 353 |
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| Sequence: | MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLL
VFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKAN
LFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQA
VPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRC
GGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFF
AFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
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| BDBM50229295 |
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| n/a |
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| Name | BDBM50229295 |
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| Synonyms: | (R)-N-((R)-1-(5-(5-chloro-3-fluoro-2-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)-3-fluoropyridin-2-yl)ethyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide | CHEMBL402831 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H16ClF5N4O3 |
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| Mol. Mass. | 490.811 |
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| SMILES | C[C@@H](NC(=O)[C@@](C)(O)C(F)(F)F)c1ncc(cc1F)-c1cc(Cl)cc(F)c1-c1noc(C)n1 |r| |
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| Structure | 
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