Reaction Details |
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Target | B1 bradykinin receptor |
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Ligand | BDBM50371333 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_463209 (CHEMBL947206) |
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Ki | 0.35±n/a nM |
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Citation | Wood, MR; Schirripa, KM; Kim, JJ; Kuduk, SD; Chang, RK; Di Marco, CN; DiPardo, RM; Wan, BL; Murphy, KL; Ransom, RW; Chang, RS; Holahan, MA; Cook, JJ; Lemaire, W; Mosser, SD; Bednar, RA; Tang, C; Prueksaritanont, T; Wallace, AA; Mei, Q; Yu, J; Bohn, DL; Clayton, FC; Adarayn, ED; Sitko, GR; Leonard, YM; Freidinger, RM; Pettibone, DJ; Bock, MG Alpha-hydroxy amides as a novel class of bradykinin B1 selective antagonists. Bioorg Med Chem Lett18:716-20 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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B1 bradykinin receptor |
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Name: | B1 bradykinin receptor |
Synonyms: | B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor |
Type: | Enzyme |
Mol. Mass.: | 40508.87 |
Organism: | Homo sapiens (Human) |
Description: | P46663 |
Residue: | 353 |
Sequence: | MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLL
VFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKAN
LFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQA
VPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRC
GGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFF
AFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
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BDBM50371333 |
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n/a |
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Name | BDBM50371333 |
Synonyms: | CHEMBL256671 |
Type | Small organic molecule |
Emp. Form. | C19H16Cl2F4N2O4 |
Mol. Mass. | 483.241 |
SMILES | COC(=O)c1c(Cl)cc(Cl)cc1-c1cnc([C@@H](C)NC(=O)[C@@](C)(O)C(F)(F)F)c(F)c1 |
Structure |
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