| Reaction Details |
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 | Report a problem with these data |
| Target | Intermediate conductance calcium-activated potassium channel protein 4 |
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| Ligand | BDBM50371384 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_463302 |
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| IC50 | 15±n/a nM |
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| Citation |  McNaughton-Smith GA; Burns JF; Stocker JW; Rigdon GC; Creech C; Arrington S; Shelton T; de Franceschi L Novel inhibitors of the Gardos channel for the treatment of sickle cell disease. J Med Chem 51:976-82 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Intermediate conductance calcium-activated potassium channel protein 4 |
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| Name: | Intermediate conductance calcium-activated potassium channel protein 4 |
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| Synonyms: | IK1 | IKCa1 | KCa4 | Putative Gardos channel | SK4 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47723.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1361891 |
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| Residue: | 427 |
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| Sequence: | MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFGGCSWALYLFL
VKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALTGRQAAQIVLELVVCGLHPA
PVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYR
SIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLSDT
LWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHN
FMMDIQYTKEMKESAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINAFRQVRLKHRK
LREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQIDTLAGKLDALTELLSTALGPRQLP
EPSQQSK
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| BDBM50371384 |
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| n/a |
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| Name | BDBM50371384 |
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| Synonyms: | CHEMBL270071 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H16FNO |
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| Mol. Mass. | 305.3455 |
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| SMILES | NC(=O)C(c1ccccc1)(c1ccccc1)c1ccccc1F |
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| Structure | 
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