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TargetIntermediate conductance calcium-activated potassium channel protein 4
LigandBDBM50371386
Substrate/Competitorn/a
Meas. Tech.ChEMBL_463302
IC50 17±n/a nM
Citation McNaughton-Smith GABurns JFStocker JWRigdon GCCreech CArrington SShelton Tde Franceschi L Novel inhibitors of the Gardos channel for the treatment of sickle cell disease. J Med Chem 51:976-82 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Intermediate conductance calcium-activated potassium channel protein 4
Name:Intermediate conductance calcium-activated potassium channel protein 4
Synonyms:IK1 | IKCa1 | KCa4 | Putative Gardos channel | SK4
Type:PROTEIN
Mol. Mass.:47723.22
Organism:Homo sapiens (Human)
Description:ChEMBL_1361891
Residue:427
Sequence:
MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFGGCSWALYLFL
VKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALTGRQAAQIVLELVVCGLHPA
PVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYR
SIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLSDT
LWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHN
FMMDIQYTKEMKESAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINAFRQVRLKHRK
LREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQIDTLAGKLDALTELLSTALGPRQLP
EPSQQSK
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BDBM50371386
n/a
NameBDBM50371386
Synonyms:CHEMBL260953
TypeSmall organic molecule
Emp. Form.C20H14F3NO
Mol. Mass.341.3265
SMILESNC(=O)C(c1ccc(F)cc1)(c1ccc(F)cc1)c1cccc(F)c1
Structure
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