Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetIntermediate conductance calcium-activated potassium channel protein 4
LigandBDBM50371390
Substrate/Competitorn/a
Meas. Tech.ChEMBL_463302 (CHEMBL948111)
IC50 10±n/a nM
Citation McNaughton-Smith, GABurns, JFStocker, JWRigdon, GCCreech, CArrington, SShelton, Tde Franceschi, L Novel inhibitors of the Gardos channel for the treatment of sickle cell disease. J Med Chem51:976-82 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Intermediate conductance calcium-activated potassium channel protein 4
Name:Intermediate conductance calcium-activated potassium channel protein 4
Synonyms:IK1 | IKCA1 | KCA4 | KCNN4 | KCNN4_HUMAN | Putative Gardos channel | SK4
Type:PROTEIN
Mol. Mass.:47723.22
Organism:Homo sapiens (Human)
Description:ChEMBL_1361891
Residue:427
Sequence:
MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFGGCSWALYLFL
VKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALTGRQAAQIVLELVVCGLHPA
PVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYR
SIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLSDT
LWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHN
FMMDIQYTKEMKESAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINAFRQVRLKHRK
LREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQIDTLAGKLDALTELLSTALGPRQLP
EPSQQSK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50371390
n/a
NameBDBM50371390
Synonyms:CHEMBL272039
TypeSmall organic molecule
Emp. Form.C20H14F3NO
Mol. Mass.341.3265
SMILESNC(=O)C(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccccc1F
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: