| Reaction Details |
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 | Report a problem with these data |
| Target | C-X-C chemokine receptor type 3 |
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| Ligand | BDBM50229439 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_463732 (CHEMBL932090) |
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| IC50 | 0.7±n/a nM |
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| Citation |  Du, X; Chen, X; Mihalic, JT; Deignan, J; Duquette, J; Li, AR; Lemon, B; Ma, J; Miao, S; Ebsworth, K; Sullivan, TJ; Tonn, G; Collins, TL; Medina, JC Design and optimization of imidazole derivatives as potent CXCR3 antagonists. Bioorg Med Chem Lett18:608-13 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-X-C chemokine receptor type 3 |
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| Name: | C-X-C chemokine receptor type 3 |
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| Synonyms: | AAO92295.1 | C-X-C chemokine receptor type 3 | C-X-C chemokine receptor type 3 (CXCR3) | C-X-C chemokine receptor type 3 (CXCR3A) | CXCR3 | CXCR3A | CXCR3_HUMAN | GPR9 | chemokine (C-X-C motif) receptor 3 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 40665.65 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 368 |
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| Sequence: | MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALY
SLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFG
SGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCL
LFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILA
VLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAK
SVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSET
SEASYSGL
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| BDBM50229439 |
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| n/a |
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| Name | BDBM50229439 |
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| Synonyms: | (R)-N-(1-(1-(4-cyanophenyl)-4-phenyl-1H-imidazol-2-yl)ethyl)-N-(2-(ethylsulfonyl)ethyl)-2-(4-fluoro-3-(trifluoromethyl)phenyl)acetamide | CHEMBL403036 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H28F4N4O3S |
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| Mol. Mass. | 612.638 |
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| SMILES | CCS(=O)(=O)CCN([C@H](C)c1nc(cn1-c1ccc(cc1)C#N)-c1ccccc1)C(=O)Cc1ccc(F)c(c1)C(F)(F)F |
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| Structure | 
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