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TargetFalcipain 2
LigandBDBM50371566
Substrate/Competitorn/a
Meas. Tech.ChEMBL_463775 (CHEMBL931126)
Ki 370±n/a nM
Citation Ettari, RNizi, EDi Francesco, MEDude, MAPradel, GVicík, RSchirmeister, TMicale, NGrasso, SZappalà, M Development of peptidomimetics with a vinyl sulfone warhead as irreversible falcipain-2 inhibitors. J Med Chem51:988-96 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Falcipain 2
Name:Falcipain 2
Synonyms:Cysteine protease falcipain-2 | Falcipain 2 | Falcipain-2
Type:Enzyme
Mol. Mass.:55912.60
Organism:Plasmodium falciparum
Description:Recombinant falcipain-2.
Residue:484
Sequence:
MDYNMDYAPHEVISQQGERFVDKYVDRKILKNKKSLLVIISLSVLSVVGFVLFYFTPNSR
KSDLFKNSSVENNNDDYIINSLLKSPNGKKFIVSKIDEALSFYDSKKNDINKYNEGNNNN
NADFKGLSLFKENTPSNNFIHNKDYFINFFDNKFLMNNAEHINQFYMFIKTNNKQYNSPN
EMKERFQVFLQNAHKVNMHNNNKNSLYKKELNRFADLTYHEFKNKYLSLRSSKPLKNSKY
LLDQMNYEEVIKKYRGEENFDHAAYDWRLHSGVTPVKDQKNCGSCWAFSSIGSVESQYAI
RKNKLITLSEQELVDCSFKNYGCNGGLINNAFEDMIELGGICPDGDYPYVSDAPNLCNID
RCTEKYGIKNYLSVPDNKLKEALRFLGPISISVAVSDDFAFYKEGIFDGECGDQLNHAVM
LVGFGMKEIVNPLTKKGEKHYYYIIKNSWGQQWGERGFINIETDESGLMRKCGLGTDAFI
PLIE
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  Blast E-value cutoff:
BDBM50371566
n/a
NameBDBM50371566
Synonyms:CHEMBL407354
TypeSmall organic molecule
Emp. Form.C30H26ClF3N4O6S
Mol. Mass.663.064
SMILESCS(=O)(=O)C=CCNC(=O)CN1c2ccccc2C(=N[C@H](COC(=O)Nc2ccc(Cl)cc2C(F)(F)F)C1=O)c1ccccc1 |w:5.5,c:19|
Structure
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