| Reaction Details |
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 | Report a problem with these data |
| Target | B1 bradykinin receptor |
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| Ligand | BDBM50371656 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_463823 (CHEMBL948902) |
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| Ki | 1.2±n/a nM |
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| Citation |  Feng, DM; DiPardo, RM; Wai, JM; Chang, RK; Di Marco, CN; Murphy, KL; Ransom, RW; Reiss, DR; Tang, C; Prueksaritanont, T; Pettibone, DJ; Bock, MG; Kuduk, SD A new class of bradykinin B1 receptor antagonists with high oral bioavailability and minimal PXR activity. Bioorg Med Chem Lett18:682-7 (2008) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| B1 bradykinin receptor |
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| Name: | B1 bradykinin receptor |
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| Synonyms: | B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 40508.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P46663 |
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| Residue: | 353 |
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| Sequence: | MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLL
VFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKAN
LFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQA
VPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRC
GGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFF
AFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
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| BDBM50371656 |
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| n/a |
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| Name | BDBM50371656 |
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| Synonyms: | CHEMBL401619 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H19Cl2F3N4O4 |
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| Mol. Mass. | 543.323 |
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| SMILES | C[C@@H](NC(=O)C1(CC1)NC(=O)c1ccon1)c1ncc(cc1F)-c1cc(Cl)cc(Cl)c1OCC(F)F |
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| Structure | 
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