Reaction Details |
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Target | C-X-C chemokine receptor type 2 |
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Ligand | BDBM50371771 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_464067 (CHEMBL949060) |
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IC50 | 2±n/a nM |
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Citation | Walters, I; Austin, C; Austin, R; Bonnert, R; Cage, P; Christie, M; Ebden, M; Gardiner, S; Grahames, C; Hill, S; Hunt, F; Jewell, R; Lewis, S; Martin, I; David Nicholls, na; David Robinson, na Evaluation of a series of bicyclic CXCR2 antagonists. Bioorg Med Chem Lett18:798-803 (2008) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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C-X-C chemokine receptor type 2 |
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Name: | C-X-C chemokine receptor type 2 |
Synonyms: | C-X-C chemokine receptor type 2 (CXCR-2) | C-X-C chemokine receptor type 2 (CXCR2) | CD_antigen=CD182 | CDw128b | CXCR-2 | CXCR2 | CXCR2_HUMAN | Chemokine receptor type 2 (CXCR2) | GRO/MGSA receptor | High affinity interleukin-8 receptor B | IL-8 receptor type 2 | IL-8R B | IL8RB | Interleukin-8 receptor B |
Type: | Protein |
Mol. Mass.: | 40767.88 |
Organism: | Homo sapiens (Human) |
Description: | P25025 |
Residue: | 360 |
Sequence: | MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFL
LSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCK
VVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPV
LLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFK
AHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATE
ILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
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BDBM50371771 |
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n/a |
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Name | BDBM50371771 |
Synonyms: | CHEMBL271012 |
Type | Small organic molecule |
Emp. Form. | C15H15FN4O2S2 |
Mol. Mass. | 366.434 |
SMILES | C[C@H](CO)Nc1[nH]c(SCc2ccccc2F)nc2nc(=O)sc12 |
Structure |
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