| Reaction Details |
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 | Report a problem with these data |
| Target | Melanin-concentrating hormone receptor 1 |
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| Ligand | BDBM50371872 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_464118 (CHEMBL948281) |
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| Ki | 3±n/a nM |
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| Citation |  Erickson, SD; Banner, B; Berthel, S; Conde-Knape, K; Falcioni, F; Hakimi, I; Hennessy, B; Kester, RF; Kim, K; Ma, C; McComas, W; Mennona, F; Mischke, S; Orzechowski, L; Qian, Y; Salari, H; Tengi, J; Thakkar, K; Taub, R; Tilley, JW; Wang, H Potent, selective MCH-1 receptor antagonists. Bioorg Med Chem Lett18:1402-6 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanin-concentrating hormone receptor 1 |
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| Name: | Melanin-concentrating hormone receptor 1 |
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| Synonyms: | G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 45976.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays. |
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| Residue: | 422 |
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| Sequence: | MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARL
WEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTIC
LLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHF
GETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALS
FISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRI
LQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVY
LYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESK
GT
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| BDBM50371872 |
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| n/a |
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| Name | BDBM50371872 |
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| Synonyms: | CHEMBL257280 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H34N4O2 |
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| Mol. Mass. | 458.5952 |
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| SMILES | CO[C@@H]1CN(C[C@H]2Cc3ccc(cc3C2)C#N)CC[C@H]1n1c(nc2cc(C)ccc12)C(C)(C)O |
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| Structure | 
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