| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine receptor A2a |
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| Ligand | BDBM50372025 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_464500 (CHEMBL931999) |
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| IC50 | 100±n/a nM |
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| Citation |  Mantell, SJ; Stephenson, PT; Monaghan, SM; Maw, GN; Trevethick, MA; Yeadon, M; Keir, RF; Walker, DK; Jones, RM; Selby, MD; Batchelor, DV; Rozze, S; Chavaroche, H; Hobson, TJ; Dodd, PG; Lemaitre, A; Wright, KN; Stuart, EF Inhaled adenosine A(2A) receptor agonists for the treatment of chronic obstructive pulmonary disease. Bioorg Med Chem Lett18:1284-7 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosine receptor A2a |
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| Name: | Adenosine receptor A2a |
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| Synonyms: | A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 44716.46 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P29274 |
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| Residue: | 412 |
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| Sequence: | MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI
PFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTR
AKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF
NFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVG
LFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR
KIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNG
YALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
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| BDBM50372025 |
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| n/a |
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| Name | BDBM50372025 |
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| Synonyms: | CHEMBL401571 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H40N6O4 |
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| Mol. Mass. | 572.6978 |
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| SMILES | COC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NCC(c3ccccc3)c3ccccc3)nc(CNC3CCCCC3)nc12 |
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| Structure | 
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