| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 1 |
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| Ligand | BDBM50234080 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_464918 (CHEMBL946975) |
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| IC50 | 2000±n/a nM |
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| Citation |  Paris, M; Porcelloni, M; Binaschi, M; Fattori, D Histone deacetylase inhibitors: from bench to clinic. J Med Chem51:1505-29 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 1 |
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| Name: | Histone deacetylase 1 |
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| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55090.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13547 |
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| Residue: | 482 |
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| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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| BDBM50234080 |
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| n/a |
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| Name | BDBM50234080 |
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| Synonyms: | CHEMBL258813 | N-(2-aminophenyl)-4-(3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)prop-1-enyl)benzamide |
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| Type | Small organic molecule |
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| Emp. Form. | C25H22N6O |
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| Mol. Mass. | 422.4818 |
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| SMILES | Nc1ccccc1NC(=O)c1ccc(\C=C\CNc2nccc(n2)-c2cccnc2)cc1 |
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| Structure | 
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