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TargetIsoprenyl transferase
LigandBDBM50372778
Substrate/Competitorn/a
Meas. Tech.ChEMBL_465860 (CHEMBL951083)
IC50 1800±n/a nM
Citation Peukert, SSun, YZhang, RHurley, BSabio, MShen, XGray, CDzink-Fox, JTao, JCebula, RWattanasin, S Design and structure-activity relationships of potent and selective inhibitors of undecaprenyl pyrophosphate synthase (UPPS): tetramic, tetronic acids and dihydropyridin-2-ones. Bioorg Med Chem Lett18:1840-4 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Isoprenyl transferase
Name:Isoprenyl transferase
Synonyms:Di-trans,poly-cis-decaprenylcistransferase | Ditrans,polycis-undecaprenyl-diphosphate synthase | ISPT_STRPN | UDS | UPP synthase | Undecaprenyl diphosphate synthase | Undecaprenyl pyrophosphate synthase | uppS
Type:PROTEIN
Mol. Mass.:28705.02
Organism:Streptococcus pneumoniae
Description:ChEMBL_465860
Residue:252
Sequence:
MFGFFKKDKAVEVEVPTQVPAHIGIIMDGNGRWAKKRMQPRVFGHKAGMEALQTVTKAAN
KLGVKVITVYAFSTENWTRPDQEVKFIMNLPVEFYDNYVPELHANNVKIQMIGETDRLPK
QTFEALTKAEELTKNNTGLILNFALNYGGRAEITQALKLISQDVLDAKINPGDITEELIG
NYLFTQHLPKDLRDPDLIIRTSGELRLSNFLPWQGAYSELYFTDTLWPDFDEAALQEAIL
AYNRRHRRFGGV
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  Blast E-value cutoff:
BDBM50372778
n/a
NameBDBM50372778
Synonyms:CHEMBL403226
TypeSmall organic molecule
Emp. Form.C24H26N2O3
Mol. Mass.390.4748
SMILESO=C(Nc1ccc(cc1)C1CCCCC1)C1C(=O)NC(Cc2ccccc2)C1=O
Structure
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