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TargetC-C chemokine receptor type 3
LigandBDBM50231358
Substrate/Competitorn/a
Meas. Tech.ChEMBL_465951
IC50 0.15±n/a nM
Citation Santella JBGardner DSYao WShi CReddy PTebben AJDeLucca GVWacker DAWatson PSWelch PKWadman EADavies PSolomon KAGraden DMYeleswaram SMandlekar SKariv IDecicco CPKo SSCarter PHDuncia JV From rigid cyclic templates to conformationally stabilized acyclic scaffolds. Part I: the discovery of CCR3 antagonist development candidate BMS-639623 with picomolar inhibition potency against eosinophil chemotaxis. Bioorg Med Chem Lett 18:576-85 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
C-C chemokine receptor type 3
Name:C-C chemokine receptor type 3
Synonyms:C-C CKR-3 | CC-CKR-3 | CCR-3 | CCR3 | CD_antigen=CD193 | CKR3
Type:PROTEIN
Mol. Mass.:40925.26
Organism:Macaca fascicularis
Description:ChEMBL_465951
Residue:355
Sequence:
MTTSLDTVETFGPTSYDDDMGLLCEKADVGALIAQFVPPLYSLVFMVGLLGNVVVVMILI
KYRRLRIMTNIYLLNLAISDLLFLFTLPFWIHYVRERNWVFSHGMCKVLSGFYHTGLYSE
IFFIILLTIDRYLAIVHAVFALRARTVTFGVVTSIVTWGLAVLAALPEFIFYGTEELFPE
TLCSAIYPQDTVYSWRHFHTLRMTILCLALPLLVMAICYTGIIKTLLRCPSKKKYKAIRL
IFVIMAVFFIFWTPYNVAILISTYQSILFGPDCERSKHLDLFVLVTEVIAYSHCWVNPVI
YAFVGERFRKYLRHFFHRHVLMHPGKYIPFLPSEKLERTSSVSPSTAEPELSIVF
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  Blast E-value cutoff:
BDBM50231358
n/a
NameBDBM50231358
Synonyms:1-((2R,3S)-4-((S)-3-(4-fluorobenzyl)piperidin-1-yl)-3-hydroxybutan-2-yl)-3-(3-(1-methyl-1H-tetrazol-5-yl)phenyl)urea | 1-{(1R,2S)-3-[(S)-3-(4-Fluoro-benzyl)-piperidin-1-yl]-2-hydroxy-1-methyl-propyl}-3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea | BMS-639623 | CHEMBL399495
TypeSmall organic molecule
Emp. Form.C25H32FN7O2
Mol. Mass.481.5657
SMILESC[C@@H](NC(=O)Nc1cccc(c1)-c1nnnn1C)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 |r|
Structure
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