Reaction Details |
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Target | Farnesyl pyrophosphate synthase |
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Ligand | BDBM50226002 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_466619 (CHEMBL924793) |
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Ki | 97500±n/a nM |
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Citation | Dunford, JE; Kwaasi, AA; Rogers, MJ; Barnett, BL; Ebetino, FH; Russell, RG; Oppermann, U; Kavanagh, KL Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase. J Med Chem51:2187-95 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Farnesyl pyrophosphate synthase |
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Name: | Farnesyl pyrophosphate synthase |
Synonyms: | Dimethylallyltranstransferase | FDPS | FPP synthase | FPP synthetase | FPPS_HUMAN | FPS | Farnesyl diphosphate synthase | Farnesyl diphosphate synthase (FPPS) | Farnesyl diphosphate synthetase | Farnesyl pyrophosphate synthase (FPPS) | Farnesyl pyrophosphate synthetase | Geranyltranstransferase | KIAA1293 | P14324 |
Type: | Enzyme |
Mol. Mass.: | 48272.89 |
Organism: | Homo sapiens (Human) |
Description: | P14324 |
Residue: | 419 |
Sequence: | MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRA
LCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAI
GGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRG
QICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLD
LLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLE
MGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKE
AEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
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BDBM50226002 |
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n/a |
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Name | BDBM50226002 |
Synonyms: | (R)-2-hydroxy-2-phosphono-3-(pyridin-3-yl)propanoic acid | 2-hydroxy-2-phosphono-3-(pyridin-3-yl)propanoic acid | 3-(3-Pyridyl)-2-hydroxy-2-phosphonopropanoic acid | CHEMBL397829 |
Type | Small organic molecule |
Emp. Form. | C8H10NO6P |
Mol. Mass. | 247.1419 |
SMILES | OC(=O)C(O)(Cc1cccnc1)P(O)(O)=O |
Structure |
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